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Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity. | LitMetric
- The text discusses polyoxometalates (POMs) and introduces a new subclass called polyoxometal clusters (POMCs) that feature binuclear MoO clusters linked by oxo- and organic ligands.
- The new POMCs are synthesized through ampoule methods and are found to be soluble and stable in water, allowing for further study.
- The research highlights the biological potential of these compounds, showing promising antiviral activity against the H5N1 strain of the influenza A virus, along with their effects on normal and cancer cells.
Article Abstract
Among well-studied and actively developing compounds are polyoxometalates (POMs), which show application in many fields. Extending this class of compounds, we introduce a new subclass of polyoxometal clusters (POMCs) [MoO(μ-L)] (L = pyrazolate (pz) or triazolate (1,2,3-trz or 1,2,4-trz)), structurally similar to POM, but containing binuclear MoO clusters linked by bridging oxo- and organic ligands. The complexes obtained by ampoule synthesis from the binuclear cluster [MoO(CO)(HO)] in a melt of an organic ligand are soluble and stable in aqueous solutions. In addition to the detailed characterization in solid state and in aqueous solution, the biological properties of the compounds on normal and cancer cells were investigated, and antiviral activity against influenza A virus (subtype H5N1) was demonstrated.
