Multiple Internet of Healthcare Things (IoHT)-based devices have been utilized as sensing methodologies for human locomotion decoding to aid in applications related to e-healthcare. Different measurement conditions affect the daily routine monitoring, including the sensor type, wearing style, data retrieval method, and processing model. Currently, several models are present in this domain that include a variety of techniques for pre-processing, descriptor extraction, and reduction, along with the classification of data captured from multiple sensors. However, such models consisting of multiple subject-based data using different techniques may degrade the accuracy rate of locomotion decoding. Therefore, this study proposes a deep neural network model that not only applies the state-of-the-art Quaternion-based filtration technique for motion and ambient data along with background subtraction and skeleton modeling for video-based data, but also learns important descriptors from novel graph-based representations and Gaussian Markov random-field mechanisms. Due to the non-linear nature of data, these descriptors are further utilized to extract the codebook via the Gaussian mixture regression model. Furthermore, the codebook is provided to the recurrent neural network to classify the activities for the locomotion-decoding system. We show the validity of the proposed model across two publicly available data sampling strategies, namely, the HWU-USP and LARa datasets. The proposed model is significantly improved over previous systems, as it achieved 82.22% and 82.50% for the HWU-USP and LARa datasets, respectively. The proposed IoHT-based locomotion-decoding model is useful for unobtrusive human activity recognition over extended periods in e-healthcare facilities.
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http://dx.doi.org/10.3390/mi14122204 | DOI Listing |
Development
January 2025
Department of Biology, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
Oscillatory dynamics and their modulation are crucial for cellular decision-making; however, analysing these dynamics remains challenging. Here, we present a tool that combines the light-activated adenylate cyclase mPAC with the cAMP biosensor Pink Flamindo, enabling precise manipulation and real-time monitoring of cAMP oscillation frequencies in Dictyostelium. High-frequency modulation of cAMP oscillations induced cell aggregation and multicellular formation, even at low cell densities, such as a few dozen cells.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
December 2024
Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China.
Placental development is a multifaceted process critical for a fruitful pregnancy, reinforced by a complex network of molecular pathways that synchronize trophoblast migration, differentiation, and overall placental function. This review provides an in-depth analysis of the key signaling pathways, such as Wnt, Notch, TGF-β, and VEGF, which play fundamental roles in trophoblast proliferation, invasion, and the complicated process of placental vascular development. For instance, the Wnt signaling pathway is essential to balance trophoblast stem cell proliferation and differentiation, while Notch signaling stimulates cell fate decisions and invasive behavior.
View Article and Find Full Text PDFElife
November 2024
Institute of Behavioural Neuroscience (IBN), University College London (UCL), London, United Kingdom.
During rest and sleep, memory traces replay in the brain. The dialogue between brain regions during replay is thought to stabilize labile memory traces for long-term storage. However, because replay is an internally driven, spontaneous phenomenon, it does not have a ground truth - an external reference that can validate whether a memory has truly been replayed.
View Article and Find Full Text PDFAccid Anal Prev
February 2025
School of Transportation, Southeast University, China; Jiangsu Key Laboratory of Urban ITS, China; Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies, China.
Jaywalking, as a hazardous crossing behavior, leaves little time for drivers to anticipate and respond promptly, resulting in high crossing risks. The prevalence of Autonomous Vehicle (AV) technologies has offered new solutions for mitigating jaywalking risks. In this study, we propose a risk-aware deep reinforcement learning (DRL) approach for AVs to make decisions safely and efficiently in jaywalker-vehicle interactions.
View Article and Find Full Text PDFJ Biomech
December 2024
Department of Civil and Environmental Engineering, Imperial College London, London, UK; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia. Electronic address:
Resource-intensive motion capture (mocap) systems challenge predictive deep learning applications, requiring large and diverse datasets. We tackled this by modifying generative adversarial networks (GANs) into conditional GANs (cGANs) that can generate diverse mocap data, including 15 marker trajectories, lower limb joint angles, and 3D ground reaction forces (GRFs), based on specified subject and gait characteristics. The cGAN comprised 1) an encoder compressing mocap data to a latent vector, 2) a decoder reconstructing the mocap data from the latent vector with specific conditions and 3) a discriminator distinguishing random vectors with conditions from encoded latent vectors with conditions.
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