10.1.1, a Producer of Antimicrobial Agents.

Microorganisms

Laboratory of Microbial Cell Surface Biochemistry, G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, FRC PSCBR, Russian Academy of Sciences, 5 Prosp. Nauki, Pushchino 142290, Russia.

Published: November 2023

AI Article Synopsis

  • This study examined the antimicrobial properties of a specific strain, revealing that its culture fluid contains agents effective against various bacteria.
  • The strain was found to produce outer membrane vesicles that exhibit bacteriolytic effects on both Gram-positive and Gram-negative bacteria.
  • Transcriptomic analysis highlighted numerous genes related to bacteriolytic enzymes and secondary metabolites with antimicrobial potential, emphasizing the importance of isolating and researching these antimicrobial agents.

Article Abstract

This work investigated the antimicrobial potential of 10.1.1. The culture fluid of the strain was found to contain antimicrobial agents active against , , and . was first shown to be capable of forming outer membrane vesicles, which have a bacteriolytic effect against not only Gram-positive bacteria but also against the Gram-negative pathogen . Transcriptomic analysis revealed the genes of almost all known bacteriolytic enzymes of , as well as the genes of enzymes with putative bacteriolytic activity. Also identified were genes involved in the biosynthesis of a number of secondary metabolites for which antimicrobial activities are known. This research is indicative of the relevance of isolating and studying antimicrobial agents.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10745450PMC
http://dx.doi.org/10.3390/microorganisms11122853DOI Listing

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