AI Article Synopsis
- Aspirin has long been used for treating acute coronary syndromes and preventing coronary diseases, but recent evidence questions its use, especially for primary prevention, particularly with newer drugs available.
- Studies show that P2Y12 inhibitors, when used alone, can lead to less bleeding compared to combining them with aspirin for patients with coronary artery disease.
- This review aims to discuss the evidence supporting aspirin’s role in both primary and secondary prevention related to coronary conditions and surgical procedures.
Article Abstract
Aspirin has for some time been used as a first-line treatment for acute coronary syndromes, including ST-elevation myocardial infarction, for secondary prevention of established coronary disease, and for primary prevention in patients at risk of coronary artery disease. Although aspirin has been in use for decades, the available evidence for its efficacy largely predates the introduction of other drugs, such as statins and P2Y12 inhibitors. Based on recent trials, the recommendation for aspirin use as primary prevention has been downgraded. In addition, P2Y12 inhibitors given as a single antiplatelet therapy have been associated with a lower incidence of bleeding than dual antiplatelet therapy in combination with aspirin in patients with stable and unstable coronary artery disease. The aim of this review is to discuss the role of aspirin considering the available evidence for primary prevention, secondary prevention for stable coronary artery disease or acute coronary syndromes, and after percutaneous coronary intervention or coronary artery bypass revascularization.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743767 | PMC |
| http://dx.doi.org/10.3390/jcm12247534 | DOI Listing |
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