is the teleomorph genus associated with the section comprises approximately 20 species, which are widely distributed in nature and human environments. is usually the key microorganism for the fermentation of traditional food, such as Fuzhuan brick tea, Liupao tea, Meju, and Karebushi; thus, is an important fungus in the food industry. has been extensively studied because it contains a series of interesting, structurally diverse, and biologically important secondary metabolites, including anthraquinones, benzaldehyde derivatives, and indol diketopiperazine alkaloids. These secondary metabolites have shown multiple biological activities, including antioxidative, antimicrobial, cytotoxic, antitumor, insecticidal, antimalarial, and anti-inflammatory activities. This study presents an up-to-date review of the phytochemistry and biological activities of all species. This review will provide recent advances on the secondary metabolites and their bioactivities in the genus for the first time and serve as a database for future research and drug development from the genus .
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http://dx.doi.org/10.3390/foods12244452 | DOI Listing |
Pharmacol Res
January 2025
BRIC-Institute of Bioresources and Sustainable Development (BRIC-IBSD), Department of Biotechnology, Government of India, Imphal, Manipur-795001, India; BRIC-IBSD, Mizoram Center, Aizawl, Mizoram 796005, India; BRIC-IBSD, Meghalaya Center, Shillong, Meghalaya-793009, India. Electronic address:
Natural resources have been used for food and medicine since the beginning of human civilization, and they have always been a low-cost, easily accessible source for individuals. Northeast region of India (NER) represents a significant portion of India's flora and fauna. Marginality, fragility, inaccessibility, ethnicity, and cultural diversity thrived in the region, resulting in the richest reservoir of genetic variation of bioresources.
View Article and Find Full Text PDFJ Photochem Photobiol B
January 2025
Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Sages and their beneficial secondary metabolites have been used in conventional and traditional medicine in many countries, and are extensively studied for their health effects. However, to achieve high production levels, it is crucial to optimize the cultivation conditions. The aim of our study was to determine the optimal light-emitting diode (LED) treatment strategy for promoting plant growth and polyphenol biosynthesis in S.
View Article and Find Full Text PDFBiofactors
January 2025
College of Pharmacy, Sunchon National University, Sunchon, Republic of Korea.
Stereocaulon alpinum has been found to have potential pharmaceutical properties due to the presence of secondary metabolites such as usnic acid, atranorin, and lobaric acid (LA) which have anticancer activity. On the other hand, the effect of LA on the stemness potential of colorectal cancer (CRC) cells remains unexplored, and has not yet been thoroughly investigated. In this study, we examined the inhibitory activity of LA from Stereocaulon alpinum against the stemness potential of CRC cells and investigated the possible underlying mechanisms.
View Article and Find Full Text PDFGut Microbes
December 2025
Department of Urology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Hyperoxaluria, including primary and secondary hyperoxaluria, is a disorder characterized by increased urinary oxalate excretion and could lead to recurrent calcium oxalate kidney stones, nephrocalcinosis and eventually end stage renal disease. For secondary hyperoxaluria, high dietary oxalate (HDOx) or its precursors intake is a key reason. Recently, accumulated studies highlight the important role of gut microbiota in the regulation of oxalate homeostasis.
View Article and Find Full Text PDFHeliyon
January 2025
Centre for Agriculture and Bioscience International (CABI), New Delhi, 110012, India.
Bacterial leaf blight (BLB) in rice, caused by the pathogen pv. , is a significant agricultural problem managed through chemical control and cultivating rice varieties with inherent resistance to the bacterial pathogen. Research has highlighted the potential of using antagonistic microbes which can suppress the BLB pathogen through the production of secondary metabolites like siderophores, rhamnolipids, and hydroxy-alkylquinolines offering a sustainable alternative for BLB management.
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