AI Article Synopsis

  • Oral diseases are common and negatively impact individuals' quality of life, with recent research indicating that depression contributes to their development and incidence.
  • This study utilized two-sample Mendelian randomization to explore the link between depression and 17 different oral diseases, employing various analytical methods to ensure the reliability of the results.
  • The findings confirmed a causal relationship between depression and certain oral issues, suggesting that managing depression could improve the effectiveness of treating oral diseases.

Article Abstract

Background: Globally, oral diseases are common, pose an economic burden, and significantly decline the quality of life of affected individuals. Recently, researchers have substantially highlighted the effect of depression on oral disease incidence and development. In this study, we elucidated the correlation between depression and oral diseases.

Methods: Using two-sample Mendelian randomization (MR), the association between depression and the risk of 17 oral diseases was evaluated. Three methods were used to perform MR analysis: the inverse variance-weighted, weighted median, and MR-Egger methods. Furthermore, Cochran's Q test, MR-Egger intercept test, MR Pleiotropy RESidual Sum and Outlier test, and leave-one-out analysis were performed to analyze sensitivity.

Results: After implementing multiple test corrections, we observed that genetic susceptibility to depression was associated with an increased risk of mouth ulcers, toothache, loose teeth, bleeding gums, painful gums, chronic periodontitis, chronic tonsil and adenoid diseases, peritonsillar abscess, and excessive tooth attrition. However, a causal relationship between depression and other oral diseases was not observed. Sensitivity analysis confirmed the robustness of the results.

Conclusions: We confirmed the causal relationship between depression and several oral diseases, thereby providing a novel viewpoint on the prevention and treatment of oral diseases. Our findings suggest the integration of depression control into routine clinical care to enhance the effectiveness of oral disease treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10742945PMC
http://dx.doi.org/10.3390/genes14122191DOI Listing

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