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| http://dx.doi.org/10.1136/ard.46.1.84 | DOI Listing |
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Allopurinol desensitisation protocol for chronic untreated tophaceous gout.
BMJ Case Rep
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Internal Medicine Department, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Hypersensitivity to Febuxostat in a Patient with a Previous Allopurinolinduced Steven-Johnson Syndrome: A Case Report of Treatment with a Slow Desensitization Protocol.
Endocr Metab Immune Disord Drug Targets
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Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine and Clinical Oncology, Bari University "Aldo Moro", Bari, Italy.
Background: We report the case of a 43-year-old Chinese male with Tophaceous gout who had been living in Italy for some years.
Case Presentation: Previous treatments with allopurinol had induced Steven Johnson syndrome, dictating a switch to febuxostat 80 mg daily. After two years of treatment with febuxostat, he developed a diffuse maculopapular rash with severe itching.
Prevention of Drug Hypersensitivity Reactions: Prescreening and Premedication.
J Allergy Clin Immunol Pract
August 2021
Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.
Drug hypersensitivity reactions (DHR) are heterogeneous in their pathomechanisms, clinical presentation, severity, and outcomes. Novel DHR mechanisms, phenotypes, and endotypes have been described. The key to prevention from further exposure to the culprit drugs involves correct identification of the putative drug through a combination of in vitro and/or in vivo tests, accurate drug allergy labeling and reporting, and electronic decision support systems within electronic medical records to prevent future accidental prescribing.
View Article and Find Full Text PDFDrug hypersensitivity reactions in Asia: regional issues and challenges.
Asia Pac Allergy
January 2020
Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
There are geographical, regional, and ethnic differences in the phenotypes and endotypes of patients with drug hypersensitivity reactions (DHRs) in different parts of the world. In Asia, aspects of drug hypersensitivity of regional importance include IgE-mediated allergies and T-cell-mediated reactions, including severe cutaneous adverse reactions (SCARs), to beta-lactam antibiotics, antituberculous drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and radiocontrast agents. Delabeling of low-risk penicillin allergy using direct oral provocation tests without skin tests have been found to be useful where the drug plausibility of the index reaction is low.
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