AI Article Synopsis
- Multi-drug resistant Gram-negative bacteria are leading to the development of new β-lactam combination antibiotics (BLCs) like ceftolozane-tazobactam and meropenem-vaborbactam to combat these challenging pathogens.
- These new antibiotics have unique mechanisms that target specific carbapenemase-producing bacteria, providing optimism in treatment options.
- Clinical microbiology labs face challenges in accurately testing the susceptibility of these agents due to their varied effectiveness against different β-lactamases and potential resistance in certain bacterial strains.
Article Abstract
The rapid emergence of multi-drug resistant Gram-negative pathogens has driven the introduction of novel β-lactam combination agents (BLCs) to the antibiotic market: ceftolozane-tazobactam, ceftazidime-avibactam, meropenem-vaborbactam, imipenem-relebactam, cefiderocol, and sulbactam-durlobactam. These agents are equipped with innovative mechanisms that confer broad Gram-negative activity, notably against certain challenging carbapenemases. While their introduction offers a beacon of hope, clinical microbiology laboratories must navigate the complexities of susceptibility testing for these agents due to their diverse activity profiles against specific β-lactamases and the possibility of acquired resistance mechanisms in some bacterial isolates. This review explores the complexities of these novel antimicrobial agents detailing the intricacies of their application, providing guidance on the nuances of susceptibility testing, interpretation, and result reporting in clinical microbiology laboratories.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10740869 | PMC |
| http://dx.doi.org/10.3390/antibiotics12121700 | DOI Listing |
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