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Background: Nursing is a highly demanding profession involving shift-work schedules around the clock. Rest time between shifts is an issue that has gained increasing research attention in recent years, with brief rest periods (< 11 hours) between shifts coined "quick-return." Quick-return work schedules have been linked to negative health outcomes such as poor sleep quality and stress, which may create a vicious cycle that can contribute to work-family conflict.
View Article and Find Full Text PDFMigraine chronification very frequently exposes patients to the inevitable risk of excessive symptomatic intake that, in turn, prompts development of medication overuse headache (MOH). The latter further compromises headache severity establishing a vicious cycle of symptomatic intake and relapsing head pain that critically worsens the overall clinical status of patients. A great deal of attention has been focused on MOH pathogenesis, and thanks to preclinical and clinical studies knowledge about this disorder is now remarkably advanced.
View Article and Find Full Text PDFThe vicious spiral in Sudden Infant Death Syndrome.
Front Pediatr
February 2025
Department of Forensic Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Sudden Infant Death Syndrome (SIDS) is the sudden and unexpected death of an otherwise healthy infant less than 1 year of age where the cause of death remains unexplained after a thorough post-mortem investigation and evaluation of the circumstances. Epidemiological, clinical, biochemical, immunological and pathological evidence indicates that three factors must coincide for SIDS to occur: a vulnerable developmental stage of the immune system and central nervous system in the infant, predisposing factors, and external trigger events. This model is referred to as the fatal triangle or triple risk hypothesis.
View Article and Find Full Text PDFBackground: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. The worldwide increase in the incidence of IBD imposes a significant economic burden on patients and communities. Recently, numerous studies have shown that disruption of the balance between the host and microbes, known as dysbiosis, is strongly associated with the development of IBD.
View Article and Find Full Text PDFOptimised Skeletal Muscle Mass as a Key Strategy for Obesity Management.
Metabolites
February 2025
Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK.
The 'Body Mass Index' (BMI) is an anachronistic and outdated ratio that is used as an internationally accepted diagnostic criterion for obesity, and to prioritise, stratify, and outcome-assess its management options. On an individual level, the BMI has the potential to mislead, including inaccuracies in cardiovascular risk assessment. Furthermore, the BMI places excessive emphasis on a reduction in overall body weight (rather than optimised body composition) and contributes towards a misunderstanding of the quiddity of obesity and a dispassionate societal perspective and response to the global obesity problem.
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