AI Article Synopsis
- Acute digitalis intoxication is rare but serious, with a mortality rate of 15-20%.
- In 1976, a specific treatment using Fab fragments of antidigoxin antibodies significantly improved outcomes for patients, proving to be effective and safe.
- Currently, the main challenge in using this therapy is the limited availability of Fab fragments, but experimental monoclonal antibodies may provide a future solution.
Article Abstract
Acute digitalis intoxication is infrequent and severe. The mortality rate is between 15 and 20 per cent. Its treatment has been greatly improved with the appearance, in 1976, of a specific serotherapy: Fab fragments of antidigoxin antibodies. The clinical experiment reported in the literature relates to approximately one hundred cases and establishes that this therapy has a practically constant and non dangerous efficacy. The lack of availability of these fragments Fab represents presently the only obstacle to the development of this treatment, but the use of monoclonal antibodies, already available experimentally, should, in the future, circumvent this last hurdle.
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