Background: High fluoride exposure is increasingly discussed attributing to kidney injury as a causative factor. Depending on geochemistry, differential fluoride levels in drinking water are identified in different regions in Sri Lanka. However, the levels of fluoride exposure, and associations with kidney health has not been adequately studied in Sri Lanka, particularly in pediatric communities. Hence, the present study aimed to assess fluoride exposure in selected pediatric communities in the dry, wet and intermediate climatic zones in Sri Lanka, along with an assessment of renal health using urinary Cystatin-C (uCys-C), and albumin-creatinine ratio (uACR).
Methods: We conducted a cross-sectional study with school students in selected education zones representing dry (N = 331), wet (N = 152), and intermediate (N = 292) climatic zones in Sri Lanka. Fluoride contents in urine and drinking water were assessed as measures of fluoride exposure.
Results: The median (interquartile distance) urinary fluoride levels of participants in the dry, wet and intermediate zones were 1.63(1.04-2.85), 1.29(0.85-2.21), and 1.07(0.61-1.98) mg/gCr while the fluoride contents of drinking water samples were 1.76(1.36-2.30), 0.25(0.18-0.37), and 0.43(0.26-0.63) ppm respectively with significant differences among the three groups. Median uCys-C level (ng/mgCr) of the participants in intermediate zone [30.26(8.49-71.44)] was significantly low (p < 0.05) compared to that of the participants in dry zone [56.19(7.08-211.8)], and wet zone [66.29(30.43-125.20)]. The incidences of elevated uCys-C levels above reference intervals in participants of dry zone (47.7%), and wet zone (50.0%) were significantly high (p < 0.001) compared to the intermediate zone (26.4%).
Conclusion: Relatively high fluoride exposure is likely in dry and wet zone communities compared to the intermediate zone along with significantly higher incidence of uCys-C levels above reference intervals in study groups with higher fluoride exposure. However, to conclude a clear link between fluoride exposure and kidney health we need in-depth studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jtemb.2023.127367 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Subfamily evolution analysis using nuclear and chloroplast data from the same reads.
Sci Rep
January 2025
Analytical Research Center for Experimental Sciences, Saga University, Saga, Japan.
The chloroplast (cp) genome is a widely used tool for exploring plant evolutionary relationships, yet its effectiveness in fully resolving these relationships remains uncertain. Integrating cp genome data with nuclear DNA information offers a more comprehensive view but often requires separate datasets. In response, we employed the same raw read sequencing data to construct cp genome-based trees and nuclear DNA phylogenetic trees using Read2Tree, a cost-efficient method for extracting conserved nuclear gene sequences from raw read data, focusing on the Aurantioideae subfamily, which includes Citrus and its relatives.
View Article and Find Full Text PDFSpatio-temporal variation of microbial indicators of river water and treatment efficiencies of drinking water treatment plants along the upper Mahaweli River segment of Sri Lanka.
Environ Pollut
January 2025
University of Peradeniya, Peradeniya 20400, Sri Lanka. Electronic address:
The microbial pollution status of river surface water is important to ensure a river-based quality drinking water supply for the public. The present study aimed to investigate bacterial contamination status in the upper Mahaweli River, the main drinking water supplier to the hill country of Sri Lanka. Both the raw surface water and treated water, taken at 14 drinking water treatment plants (DWTPs) along the river segment of 60 km between Kotmale and Victoria reservoirs, were tested for total bacterial counts (TBC), total coliform counts (TCC) and faecal coliform counts (FCC).
View Article and Find Full Text PDFThe need for pediatric sleep education to enhance healthcare for children and adolescents: A global perspective from a survey of members of the international pediatric sleep association.
Sleep Med
December 2024
Developmental and Social Psychology, Sapienza University of Rome, Rome, Italy.
Introduction: Sleep concerns have become increasingly common over the past few decades. This study outlines the perceived needs and gaps in pediatric sleep education, drawing insights from a diverse international cohort of pediatric sleep health professionals.
Methods: International Pediatric Sleep Association (IPSA) members were invited to complete an online survey examining a variety of topics related to pediatric sleep education developed by the education committee.
Validation of the Sinhala Translation of the EORTC QLQ-INFO25: Enhancing Information Provision for Cancer Patients in Sri Lanka.
J Cancer Educ
January 2025
Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Cancer is a major health challenge globally and in Sri Lanka. Providing comprehensive information to patients is crucial for improving treatment outcomes and patient satisfaction, supported by evidence of its effectiveness in managing cancer pain. EORTC QLQ-INFO25, an information module developed by the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group, is aimed at assessing cancer patients' perception of information received during different phases of care.
View Article and Find Full Text PDFGlobal, regional, and national burden of primary liver cancer attributable to metabolic risks: an analysis of the Global Burden of Disease Study 1990-2021.
Am J Gastroenterol
January 2025
MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Background: The global burden of metabolic diseases is increasing, but estimates of their impact on primary liver cancer are uncertain. We aimed to assess the global burden of primary liver cancer attributable to metabolic risk factors, including high body mass index (BMI) and high fasting plasma glucose (FPG) levels, between 1990 and 2021.
Methods: The total number and age-standardized rates of deaths and disability-adjusted life years (DALYs) from primary liver cancer attributable to each metabolic risk factor were extracted from the Global Burden of Disease Study 1990-2021.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!