AI Article Synopsis
- This study compared outcomes of patients with localized myxoid liposarcoma treated with surgery plus adjuvant chemotherapy versus surgery alone, using a dataset of 456 patients over an 18-year period.
- Analysis revealed no significant differences in local recurrence, distant metastasis, or disease-specific survival rates between the two treatment groups in the overall cohort or specifically in high-risk patients.
- The findings suggest that adjuvant chemotherapy has a limited impact on improving patient outcomes for localized myxoid liposarcoma.
Article Abstract
Background: This study aimed to compare the local recurrence, distant metastasis and disease-specific survival rates of patients with localized myxoid liposarcoma in the surgery and adjuvant chemotherapy group versus the surgery alone group.
Methods: A total of 456 patients in the Japanese National Bone and Soft Tissue Tumour Registry database who had localized myxoid liposarcoma and underwent surgery and adjuvant chemotherapy or surgery alone between 2001 and 2019 were included in this retrospective study. The study adjusted for background differences between patients who underwent surgery and adjuvant chemotherapy (n = 228) or surgery alone (n = 228) using propensity score matching.
Results: Univariate analysis showed no significant difference in local recurrence rate between the two groups (5-year local recurrence-free survival: 98.6% [95% confidence interval: 95.9-99.6] vs. 94.0% [95% confidence interval: 89.7-96.6], P = 0.052). Univariate analysis showed no difference in the incidence of distant metastases between the two groups (5-year distant metastasis-free survival: 80.5% [95% confidence interval: 73.9-85.8] vs. 75.1% [95% confidence interval: 67.7-81.2], P = 0.508). Univariate analysis showed no difference in disease-specific survival between the two groups (5-year disease-specific survival: 92.6% [95% confidence interval: 86.1-96.2] vs. 93.2% [95% confidence interval: 87.6-96.4], P = 0.804). In the high-risk group (n = 203) with high-grade tumours and tumour size ≥10 cm, there were no significant differences in the local recurrence, distant metastasis and disease-specific survival rates between the surgery and adjuvant chemotherapy group and the surgery alone group.
Conclusion: The effect of adjuvant chemotherapy on localized myxoid liposarcoma appears to be limited.
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| http://dx.doi.org/10.1093/jjco/hyad179 | DOI Listing |
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