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Incorporating Lymph Node Size at CT as an N1 Descriptor in Clinical N Staging for Lung Cancer.
Radiology
January 2025
From the Department of Radiology and Research Institute of Radiology (Y.A., S.M.L., J.C., K.H.D., J.B.S.) and Department of Cardiothoracic Surgery (S.H.C.), University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
Background The ninth edition of the TNM classification for lung cancer revised the N2 categorization, improving patient stratification, but prognostic heterogeneity remains for the N1 category. Purpose To define the optimal size cutoff for a bulky lymph node (LN) on CT scans and to evaluate the prognostic value of bulky LN in the clinical N staging of lung cancer. Materials and Methods This retrospective study analyzed patients who underwent lobectomy or pneumonectomy for lung cancer between January 2013 and December 2021, divided into development (2016-2021) and validation (2013-2015) cohorts.
View Article and Find Full Text PDF"A quality of heart, of presence, and of really caring": toward affirmative intersex health communication in Canada.
Front Public Health
January 2025
Centre of Genomics and Policy, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Introduction: This qualitative research study aimed to better understand and help improve the Canadian context for health communication with intersex adults by centering the voices of those directly involved and impacted.
Methods: We conducted 22 semi-structured interviews with intersex individuals (14) and healthcare practitioners (HCPs, 8) from diverse areas of care. Interviews were analyzed via template thematic analysis and filtered through a conceptual lens that brought together agency-based and social-ecological models of health communication.
Versatile graceful degradation framework for bio-inspired proprioception with redundant soft sensors.
Front Robot AI
January 2025
Neuro-robotics Laboratory, Department of Robotics, Graduate School of Engineering, Tohoku University, Sendai, Japan.
Reliable proprioception and feedback from soft sensors are crucial for enabling soft robots to function intelligently in real-world environments. Nevertheless, soft sensors are fragile and are susceptible to various damage sources in such environments. Some researchers have utilized redundant configuration, where healthy sensors compensate instantaneously for lost ones to maintain proprioception accuracy.
View Article and Find Full Text PDFAgeing, clinical complexity, and exercise therapy: a multidimensional approach.
Front Sports Act Living
January 2025
Department of Internal Medicine, National Relevance and High Specialization Hospital Trust, ARNAS Civico, Di Cristina, Benfratelli, Palermo, Italy.
Ageing is a multidimensional concept related to the progressive decline in physiological functions. The decrease of physical autonomy due to the ageing process leads to frailty, which in turn is associated with disability and comorbidity. Ageing represents the primary risk factor for chronic degenerative diseases, especially involving cardiovascular, metabolic, respiratory, and osteoarticular systems, determining the decrease in activities and quality of daily life.
View Article and Find Full Text PDFExtracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity.
Front Immunol
January 2025
Inflammation and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Background: Factors leading to severe COVID-19 remain partially known. New biomarkers predicting COVID-19 severity that are also causally involved in disease pathogenesis could improve patient management and contribute to the development of innovative therapies. Autophagy, a cytosolic structure degradation pathway is involved in the maintenance of cellular homeostasis, degradation of intracellular pathogens and generation of energy for immune responses.
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