AI Article Synopsis
- Individuals with chronic kidney disease (CKD) experience significant age-related loss of muscle strength in the lower extremities, which affects blood flow within the kidneys.
- This study examined the relationship between lower extremity muscle strength/function and kidney blood flow in 276 people, both with and without CKD, using tests for muscle strength and Doppler ultrasound to measure kidney hemodynamics.
- Results showed that gait speed and performance in a chair stand test were linked to kidney blood flow, while knee extensor strength did not have the same association; lower muscle strength and function were related to increased kidney blood flow pulsatility in both groups.
Article Abstract
Age-related loss of lower extremity muscle strength is pronounced in individuals with chronic kidney disease (CKD). In contrast, an increase in intrarenal flow pulsatility results in initial age-related changes in renal hemodynamics, leading to the development of CKD. To date, it remains unclear whether lower extremity muscle strength determines elevated renal flow pulsatility. This study aimed to determine the association of lower extremity muscle strength and function with intrarenal hemodynamics in individuals with and without CKD. One hundred seventy-six individuals without CKD (aged 63 ± 9 years) and 101 individuals with CKD (aged 66 ± 8 years) were included in this study. Using Doppler ultrasound, the renal resistive index (RI) was measured as a parameter of renal hemodynamics. Knee extensor muscle strength (KES), gait speed (GS), and the 30 s chair stand test (30s-CST) were used to measure lower extremity muscle strength and function. Multivariate analyses showed that GS and 30s-CST scores were independent determinants of renal RI, whereas the KES score was not associated with renal RI in individuals with and without CKD. In the two-way analysis of covariance, renal RI was the highest in individuals with CKD who had lower KES, GS, and 30s-CST scores. Reduced lower extremity muscle strength and function are independent determinants of elevated renal flow pulsatility in individuals with and without CKD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10742463 | PMC |
| http://dx.doi.org/10.3390/geriatrics8060118 | DOI Listing |
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