AI Article Synopsis
- The management of medulloblastoma in children has evolved significantly over the last 40 years, focusing on chemotherapy to enhance survival and lessen the harmful effects of high-dose craniospinal radiation.
- Advances in molecular biology have led to improved staging and treatment strategies for this complex disease, moving beyond the previous reliance on the modified Chang's system.
- This review discusses the progression of systemic therapies for treating medulloblastoma.
Article Abstract
The management of medulloblastoma in children has dramatically changed over the past four decades, with the development of chemotherapy protocols aiming at improving survival and reducing long-term toxicities of high-dose craniospinal radiotherapy. While the staging and treatment of medulloblastoma were until recently based on the modified Chang's system, recent advances in the molecular biology of medulloblastoma have revolutionized approaches in the management of this increasingly complex disease. The evolution of systemic therapies is described in this review.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743079 | PMC |
| http://dx.doi.org/10.3390/diagnostics13243680 | DOI Listing |
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