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http://dx.doi.org/10.4103/IJO.IJO_1664_23 | DOI Listing |
Curr Opin Chem Biol
December 2024
BioEmPiRe Centre for Structural Biological EPR Spectroscopy, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK; Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK. Electronic address:
Pulsed dipolar electron paramagnetic resonance spectroscopy (PDS), combined with site-directed spin-labelling, represents a powerful tool for the investigation of biomacromolecules, emerging as a keystone approach in structural biology. Increasingly, PDS is applied to study highly complex integral membrane protein systems, such as mechanosensitive ion channels, transporters, G-protein coupled receptors, ion pumps, and outer membrane proteins elucidating their dynamics and revealing conformational ensembles. Indeed, PDS offers a platform to study intermediate or lowly-populated states that are otherwise invisible to other modern methods, such as X-ray crystallography, cryo-EM, and hydrogen-deuterium exchange-mass spectrometry.
View Article and Find Full Text PDFTalanta
December 2024
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang, 471934, China.
An europium metal organic framework (Eu-DBPA-Phen) was synthesized using 2,5-dibromoterephthalic acid (HDBPA) and 1-10-phenanthroline (Phen) as ligands. A straightforwardc quasi-ratiometric fluorescence probe was then developed for the detection of levofloxacin (LVF) by the simplistic combination of red-emitting Eu-DBPA-Phen and the inherent blue auto-fluorescence of the target. The probe exhibits the advantages of wide linear range (0.
View Article and Find Full Text PDFDev Cogn Neurosci
December 2024
Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, USA.
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The goal is to recruit over 7000 caregiver-child dyads across the United States, with 25 % of the study population comprising children exposed in utero to substances to better understanding the effects of prenatal substance exposure on fetal and child development. However, barriers of mistrust for pregnant persons who are substance involved can create challenges to recruiting and retaining this population.
View Article and Find Full Text PDFInt J Ment Health Nurs
February 2025
Department of Head and Skin, Faculty of Medicine and Health Sciences, Ghent University & Ghent University Hospital, Ghent, Belgium.
Despite advancements in promoting family engagement in mental health settings, limited involvement of family members persists in forensic mental healthcare. Forensic mental healthcare professionals face various barriers in engaging families, including a patient-centered approach and resource constraints. However, limited understanding exists of professionals' experiences with family engagement, which is crucial for improving care practices in this setting.
View Article and Find Full Text PDFWorld J Microbiol Biotechnol
December 2024
Departamento de Investigaciones Científicas y Tecnológicas, Universidad de Sonora, Blvd. Luis Donaldo Colosio s/n, entre Reforma y Sahuaripa, Edificio 7G, Col. Centro, Hermosillo, Sonora, C.P. 83000, Mexico.
Contamination of water bodies is a significant global issue that results from the deliberate release of pollutants into the environment, especially from mining and metal processing industries. The main pollutants generated by these industries are metallic wastes, particularly metals, which can cause adverse effects on the environment and human health. Therefore, it is crucial to develop effective and sustainable approaches to prevent their discharge into the environment.
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