AI Article Synopsis
- A G-rich core sequence can form various structures, including parallel G-quadruplexes and a unique hybrid topology with specific loop arrangements.
- The formation of these structures depends on the presence of thymidine sequences and other complementary DNA segments nearby.
- Understanding these favored folds provides insight into the complex behavior of G-quadruplexes in biological systems.
Article Abstract
A G-rich core sequence G-TCA-G-T-G-T-G can be designed to fold into a parallel or into two different (3+1) hybrid-type G-quadruplexes, among them an elusive topology with one lateral followed by two propeller loops. Favored folds can be rationalized based on the number of intervening thymidines and on additional complementary flanking sequences.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d3cc05625b | DOI Listing |
Publication Analysis
Top Keywords
hybrid-type g-quadruplexes
8
impact loop
4
loop length
4
length duplex
4
duplex extensions
4
extensions design
4
design hybrid-type
4
g-quadruplexes g-rich
4
g-rich core
4
core sequence
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!