Key Clinical Message: It is important to stain acid-fact bacilli on the smear of abscess puncture in addition to Gram stain to detect nontuberculous and tuberculous mycobacteria in the early phase since both can cause rare and challenging extrapulmonary manifestations.
Abstract: A 56-year-old otherwise healthy woman developed abscess from dacryocystitis in the right lower eyelid. The smear of puncture fluid showed acid-fast bacilli and was identified after a month. The early start of clarithromycin/ethambutol was switched to clarithromycin/levofloxacin. Debridement specimen after 7-month treatment showed granulomatous tissue with no bacilli.
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http://dx.doi.org/10.1002/ccr3.8364 | DOI Listing |
Microorganisms
December 2024
Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA.
Mycobacterial infections, caused by various species within the Mycobacterium genus, remain one of the main challenges to global health across the world. Understanding the complex interplay between the host and mycobacterial pathogens is essential for developing effective diagnostic and therapeutic strategies. Host long noncoding RNAs (lncRNAs) have emerged as key regulators in cellular response to bacterial infections within host cells.
View Article and Find Full Text PDFPathogens
December 2024
Respiratory Infectious Diseases Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.
Diagnosing non-tuberculous mycobacterial pulmonary disease (NTM-PD) in patients unable to produce sputum spontaneously requires invasive procedures to obtain valid respiratory specimens. In this retrospective study, we evaluated the results of microbiological tests performed on respiratory samples of 132 patients affected by NTM-PD. In the diagnostic workout, 98 patients performed both induced sputum (IS) and bronchoalveolar lavage (BAL) and were enrolled in our study.
View Article and Find Full Text PDFLasers Med Sci
January 2025
Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157th Xi 5 Road, Xi'an, 710004, PR China.
Non-tuberculous mycobacterial skin infection lead to complex and lengthy treatment cycles. Antimicrobial photodynamic therapy (aPDT) is an emerging promising approach for treating infections. This study aims to assess the effects of aPDT using curcumin as a photosensitizer (PS) on non-tuberculous mycobacteria, Mycobacterium abscessus, a subtype that has become common in dermatology in recent years.
View Article and Find Full Text PDFJAAPA
January 2025
Eunice Im is a student in the College of Human Medicine at Michigan State University in Grand Rapids, Mich. Erin Gawel is a student in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo in Buffalo, N.Y. Alyson Coppola practices at the University at Buffalo Otolaryngology in Williamsville, N.Y. Michele Carr is a professor in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Cervicofacial non-tuberculous mycobacterial infection should be a part of the differential diagnosis for immunocompetent children ages 1 to 5 years who present with painless submandibular or preauricular lymphadenopathy. Although a benign and self-limiting disease, patients can develop a chronically draining fistula if not diagnosed and treated promptly. The diagnostic process can be managed with a combination of microbiological studies, cytology, laboratory tests, and imaging studies.
View Article and Find Full Text PDFInt J Infect Dis
January 2025
Division of Internal Medicine, Japan Agricultural Cooperatives Kochi Hospital, 526-1 Myoken-aza-Nakano, Nankoku, Kochi 783-8509, Japan; Department of Community Medicine for Respirology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. Electronic address:
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