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Functional fitness and psychological well-being in older adults.
BMC Geriatr
January 2025
Institute of Health Promotion and Sport Sciences, Faculty of Education and Psychology, ELTE Eötvös Loránd University, Bogdánfy St. 12, Budapest, H-1117, Hungary.
Background: Physical fitness and functioning are related to better mental health in older age. However, which fitness components (body composition, strength, flexibility, coordination, and endurance) are more closely related to psychological well-being (PWB) is unclear.
Methods: This research examined how body mass index (BMI) and six indices of functional fitness (i.
Life satisfaction and happiness are related but distinct assessments of life quality with established links to sociodemographic and health factors. Despite a rich literature on quality of life, there remains a paucity of research on this topic among African Americans. This investigation explored (1) the sociodemographic correlates of life satisfaction and happiness and (2) how life satisfaction and happiness are related to health factors and adversity-relevant life circumstances.
View Article and Find Full Text PDFEffect of behavior modification combined with health belief model education on adherence to skin moisturizing care in patients with psoriasis vulgaris.
Sci Rep
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Nursing Department, Hangzhou Third People's Hospital, No. 38 Xihu Avenue, Shangcheng District, Hangzhou, Zhejiang, China.
To examine the impact of an educational approach incorporating behavioral modification and the Health Belief Model on the adherence to skin moisturizing care, itch severity, self-efficacy, and quality of life among individuals diagnosed with psoriasis vulgaris. A study involving 108 psoriasis vulgaris patients (November 2022-October 2023) utilized random allocation to form experimental and control groups. The control group received standard care, including medication guidance, general health education, and basic nursing support.
View Article and Find Full Text PDFTheoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies.
Sci Rep
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The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Ave., Maywood, IL, 60153, USA.
Designing and carrying out a controlled human infection (CHI) model for hepatitis C virus (HCV) is critical for vaccine development. However, key considerations for a CHI model protocol include understanding of the earliest viral-host kinetic events during the acute phase and susceptibility of the viral isolate under consideration for use in the CHI model to antiviral treatment before any infections in human volunteers can take place. Humanized mouse models lack adaptive immune responses but provide a unique opportunity to obtain quantitative understanding of early HCV kinetics and develop mathematical models to further understand viral and innate immune response dynamics during acute HCV infection.
View Article and Find Full Text PDFMultivariate stochastic modeling for transcriptional dynamics with cell-specific latent time using SDEvelo.
Nat Commun
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School of Data Science, The Chinese University of Hong Kong-Shenzhen, Shenzhen, China.
Recently, RNA velocity has driven a paradigmatic change in single-cell RNA sequencing (scRNA-seq) studies, allowing the reconstruction and prediction of directed trajectories in cell differentiation and state transitions. Most existing methods of dynamic modeling use ordinary differential equations (ODE) for individual genes without applying multivariate approaches. However, this modeling strategy inadequately captures the intrinsically stochastic nature of transcriptional dynamics governed by a cell-specific latent time across multiple genes, potentially leading to erroneous results.
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