AI Article Synopsis
- This study investigates the reliability of tuberculosis (TB) testing using interferon-gamma-release assays (IGRAs) in patients who have had COVID-19 and aims to understand the prevalence of indeterminate results after infection or vaccination.
- Through a systematic review of research articles, the study evaluates 2107 patients and finds that approximately 26% of QFT-TB tests in COVID-19 patients yield indeterminate results.
- Factors such as the severity of COVID-19, steroid treatment, and certain blood parameters were linked to higher rates of indeterminate IGRA results, suggesting a need for further research in this area.
Article Abstract
Background And Aims: The reliability of interferon-gamma-release-assays (IGRAs) for tuberculosis (TB) testing in coronavirus disease 2019 (COVID-19) patients is unknown. This study aimed to systematically review the prevalence of indeterminate TB-IGRA following SARS-CoV-2 infection or vaccination and to review associated factors.
Methods: This systematic literature review was guided according to the PRISMA guidelines by searching PubMed, Scopus, Web of Science, Clinicalkey, and Cochrane Library. Studies reporting results of TB-IGRA tests (QuantiFERON [QFT]-TB, T-SPOT.TB) in COVID-19 patients or vaccines were included. The random effects model was used to assess the prevalence of indeterminate IGRA results. Heterogeneity was evaluated using the and 95% predictive interval.
Results: Of the 273 citations screened, 12 articles were included in the final analysis including a total of 2107 patients. The overall pooled effect size proportion of indeterminate QFT-TB results, estimated in eight studies using the QFT-TB Plus assay, was 0.26 (95% CI: 0.205-0.324, = 0.158). The mean true effect size was 0.26 (95% predictive interval: [0.110-0.500]). A subgroup analysis was not undertaken due to the small number of studies. Indeterminate QFT-TB rates were associated with COVID-19 severity, steroid treatment, inflammation-related parameters, neutrophilia, and lymphopenia.
Conclusion: Indeterminate QFT-TB results in COVID-19 patients occur in almost one-quarter of tests performed. Further studies are needed to assess associated factors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10733599 | PMC |
| http://dx.doi.org/10.1002/hsr2.1695 | DOI Listing |
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