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Pertuzumab Retreatment for Human Epidermal Growth Factor Receptor 2-Positive Locally Advanced/Metastatic Breast Cancer (PRECIOUS Study): Final Overall Survival Analysis.
J Clin Oncol
January 2025
Breast Surgery, Kyoto University Graduate School of Medicine, Shogoin Sakyo-ku, Kyoto, Japan.
In the primary analysis of the open-label phase III PRECIOUS study, pertuzumab retreatment combined with trastuzumab plus chemotherapy of physician's choice (PTC) significantly improved investigator-assessed progression-free survival (PFS) compared with trastuzumab plus physician's choice chemotherapy (TC) in patients with human epidermal growth factor receptor 2 (HER2)-positive locally advanced/metastatic breast cancer (LA/mBC). Here, we report final overall survival (OS) at the median follow-up of 25.8 months.
View Article and Find Full Text PDFGenotype x environment interaction effect on grain yield of cowpea (Vigna unguiculata (L.) Walp) in Deciduous forest and Sudan savanna ecologies of Ghana.
PLoS One
January 2025
Department of Botany, University of Ghana, Legon, Ghana.
Cowpea is deemed as a food security crop due to its ability to produce significant yields under conditions where other staples fail. Its resilience in harsh environments; such as drought, heat and marginal soils; along with its nitrogen-fixing capabilities and suitability as livestock feed make cowpea a preferred choice in many farming systems across sub-Saharan Africa (SSA). Despite its importance, Cowpea yields in farmers' fields remain suboptimal, primarily due to biotic and abiotic factors and the use of either unimproved varieties or improved varieties that are not well-suited to local conditions.
View Article and Find Full Text PDFRecurrence rate of intracranial aneurysms: a systematic review and a meta-analysis comparing craniotomy and endovascular coiling.
Neurosurg Rev
January 2025
Department of Neurosurgery, Sanya Central Hospital (Hainan Third People's Hospital）, No. 1154, Jiefang Road, Sanya City, Hainan Province, 572000, China.
Patients with intracranial aneurysm (IA) are at high risk of cerebral hemorrhage, which is associated with high mortality. Craniotomy or interventional endovascular coiling are common treatment methods in clinical practice, depending on the patient's condition. However, the recurrence rate of IA after either method remains unclear.
View Article and Find Full Text PDFNext-Generation Potentiometric Sensors: A Review of Flexible and Wearable Technologies.
Biosensors (Basel)
January 2025
Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, MN 55455, USA.
In recent years, the field of wearable sensors has undergone significant evolution, emerging as a pivotal topic of research due to the capacity of such sensors to gather physiological data during various human activities. Transitioning from basic fitness trackers, these sensors are continuously being improved, with the ultimate objective to make compact, sophisticated, highly integrated, and adaptable multi-functional devices that seamlessly connect to clothing or the body, and continuously monitor bodily signals without impeding the wearer's comfort or well-being. Potentiometric sensors, leveraging a range of different solid contact materials, have emerged as a preferred choice for wearable chemical or biological sensors.
View Article and Find Full Text PDFImpact of Comorbidities on Prognosis and Treatment Outcomes in Elderly Patients with Hodgkin Lymphoma.
Clin Pract
January 2025
Division of Haematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
: Hodgkin lymphoma (HL) primarily affects young adults, but about 20% of cases occur in patients over the age of 60 years. Older individuals often have comorbidities and poorer functional status, which can affect treatment choices. : We retrospectively analyzed data from HL patients over 60 years old who were treated at our institution between January 2010 and December 2023.
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