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Network Toxicology and Molecular Docking Analysis of Tetracycline-Induced Acute Pancreatitis: Unveiling Core Mechanisms and Targets.
Toxics
December 2024
West China Center of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Acute pancreatitis (AP), induced by tetracycline, a widely used antibiotic, poses significant clinical and toxicological challenges, yet its molecular mechanisms remain unclear. This study aims to promote drug toxicology strategies for the effective investigation of the putative toxicity and potential molecular mechanisms of antibiotic drugs through the study of tetracycline in AP. Using the SwissTargetPrediction, SEA Search, Super-PRED, GeneCards, Drugbank, Online Mendelian Inheritance in Man (OMIM), and Therapeutic Target Database (TTD), we identified 259 potential targets associated with tetracycline exposure and AP.
View Article and Find Full Text PDFInsights into Within-Host Evolution and Dynamics of Oral and Intestinal Streptococci Unveil Niche Adaptation.
Int J Mol Sci
December 2024
Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology and Preventive Dentistry, Rheinisch-Westfälische Technische Hochschule (RWTH) University Hospital, 52074 Aachen, Germany.
The oral-gut axis is a complex system linking the oral cavity and gastrointestinal tract, impacting host health and microbial composition. This study investigates genetic changes and adaptive mechanisms employed by streptococci-one of the few genera capable of colonizing oral and intestinal niches-within the same individual. We conducted whole-genome sequencing (WGS) on 218 streptococcal isolates from saliva and fecal samples of 14 inflammatory bowel disease (IBD) patients and 12 healthy controls.
View Article and Find Full Text PDFUnveiling the Diverse Principles for Developing Sprayable Hydrogels for Biomedical Applications.
Biomacromolecules
January 2025
Center of Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Sprayable hydrogels have emerged as a transformative innovation in biomedical technology, offering a versatile, efficient, and minimally invasive platform for various clinical applications. They form gels upon tissue contact, enabling seamless application on even complex surfaces. This property is especially useful in wound care, drug delivery, and tissue engineering, where localized and sustained release of therapeutics is essential.
View Article and Find Full Text PDFUnveiling microbial dynamics in terasi spontaneous fermentation: Insights into glutamate and GABA production.
Curr Res Food Sci
December 2024
Veterinary Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Terasi, a traditional Indonesian seafood product made from shrimp, undergoes fermentation facilitated by a consortium of microorganisms, including Lactic Acid Bacteria (LAB) and yeast, which contribute to its distinctive umami flavor. This study investigates the microbial dynamics and production of key metabolites, including γ-aminobutyric acid (GABA), during terasi fermentation. Total Plate Count (TPC) and High-Performance Liquid Chromatography (HPLC) were used to monitor changes in glutamate and GABA levels, with glutamate increasing from 105.
View Article and Find Full Text PDFNanoparticle trends and hotspots in lung cancer diagnosis from 2006-2023: a bibliometric analysis.
Front Oncol
December 2024
Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China.
Article Synopsis
- Lung cancer is the most prevalent and deadliest cancer globally, often detected late, which limits treatment options and worsens outcomes; advancements in nanotechnology offer promising approaches for earlier diagnosis through nanoparticles.
- The study used bibliometric tools to analyze 966 articles on this topic from 2006 to 2023, revealing an increasing trend in research, with China leading in publications, followed by the U.S. and India, and highlighting key areas of focus such as biomarkers and gold/silver nanoparticles.
- This research provides valuable insights into existing literature and trends, aiding scholars in understanding the landscape of nanoparticles in lung cancer research and guiding future experimental designs.
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