In this issue of Neuron, Uribe-Arias et al. show that, in larval zebrafish, astrocyte-like cells exhibit calcium responses to norepinephrine during behavioral-state transitions and alter neuronal response properties. Thus, astroglia can sculpt neuronal dynamics in behaviorally meaningful ways.
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| http://dx.doi.org/10.1016/j.neuron.2023.10.026 | DOI Listing |
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Article Synopsis
- - Both neurons and glia use neuromodulatory substances to communicate, but how they compute information in these networks is not fully understood.
- - In larval zebrafish, norepinephrine causes quick excitation followed by delayed behavior inhibition, which is partially mediated by astroglial release of ATP that converts to adenosine to suppress behavior.
- - This study, along with another involving mice, highlights the important role of astroglial purinergic signaling in regulating behavior and brain activity transitions driven by norepinephrine, showcasing a conserved mechanism across species.
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