How are human-specific brain bioenergetics and excitability connected? In this Neuron issue, Shen et al. reveal a human-specific interaction between RACK1 mRNA and FMRP. Reducing RACK1 mimics FMRP-dependent excitability and mitochondrial phenotypes, which can be reversed with mitochondrial-protective drugs. These findings suggest that FMRP-mediated translation adapts mitochondria to excitability energy demands.
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| http://dx.doi.org/10.1016/j.neuron.2023.10.031 | DOI Listing |
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