Biomechanical analysis of peri-prosthetic bone response to hybrid threaded zirconia dental implants: An in silico model.

The biomechanical response of mandibular bone determines primary stability and concomitant osseointegration of dental implants. This study explores the impact of nature of loading and bone conditions on biomechanical response of hybrid threaded single-piece zirconia dental implants. To develop such understanding, three implants (SQ_V, V_BUT, and V_V), with different combinations of threads, square (SQ), buttress (BUT), and triangular (V), have been investigated. Finite Element Analysis (FEA) was carried out to simulate implantation at the molar position of mandible of varying densities under axial (≤500 N) and oblique (118.2 N) loadings. Patient-specific bone conditions (for a wider population) were considered by scaling the density and the elastic modulus of mandible to represent, 'weak', 'healthy', and 'strong' bone conditions. FEA results revealed that SQ_V and V_BUT implants exhibited a better biomechanical response without significant variation (<0.5%) in von Mises stress, regardless of bone density and axial loadings. These implants are predicted to perform with clinically acceptable factor of safety under investigated implantation scenarios, whereas V_BUT implant showed a larger variation (∼±12%). FEA simulation with oblique loading further validated such results. The 'weak' bone conditions resulted in maximum peri-implant microstrain, whereas 'strong and healthy' bone exhibited values close to the permissible range of physiological remodeling. The maximum micromotion (∼12.3 ± 6.2 μm for 'weak' bone) at bone-implant interface suggested that implant loosening and impaired osseointegration will not occur in any of selected virtual implantation cases. Both SQ_V and V_BUT implants will be considered further in implant development, involving manufacturing and product prototype validation. Taken together, the critical analysis of FEA results indicates a significant impact of bone density and distinct combinations of external threads on the biomechanical responses, in both the implant and the surrounding bone.