AI Article Synopsis
- Some animals can regenerate lost structures after injury, but this process must be tightly regulated to prevent abnormal growth and ensure proper tissue organization.
- Researchers using the Drosophila wing model found that reduced levels of the RNA-regulator Brat lead to excessive regeneration, resulting in malformed adult wings missing important sensory bristles.
- The study suggests that Brat plays a crucial role in controlling pro-regeneration gene expression, which is essential for maintaining the correct structure of regenerating tissues.
Article Abstract
Some animals respond to injury by inducing new growth to regenerate the lost structures. This regenerative growth must be carefully controlled and constrained to prevent aberrant growth and to allow correct organization of the regenerating tissue. However, the factors that restrict regenerative growth have not been identified. Using a genetic ablation system in the Drosophila wing imaginal disc, we have identified one mechanism that constrains regenerative growth, impairment of which also leads to erroneous patterning of the final appendage. Regenerating discs with reduced levels of the RNA-regulator Brain tumor (Brat) exhibit enhanced regeneration, but produce adult wings with disrupted margins that are missing extensive tracts of sensory bristles. In these mutants, aberrantly high expression of the pro-growth factor Myc and its downstream targets likely contributes to this loss of cell-fate specification. Thus, Brat constrains the expression of pro-regeneration genes and ensures that the regenerating tissue forms the proper final structure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10769103 | PMC |
| http://dx.doi.org/10.1371/journal.pgen.1011103 | DOI Listing |
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