Metronidazole-loaded polydopamine nanomedicine with antioxidant and antibacterial bioactivity for periodontitis.

This study focused on treating periodontitis with bacterial infection and local over accumulation of reactive oxygen species. Polydopamine nanoparticles (PDA NPs) were exploited as efficient carriers for encapsulated metronidazole (MNZ). The therapeutic efficacy and biocompatibility of PDA@MNZ NPs were investigated through both and studies. The nanodrug PDA@MNZ NPs were successfully fabricated, with well-defined physicochemical characteristics. , the PDA@MNZ NPs effectively eliminated intracellular reactive oxygen species and inhibited the growth of . Moreover, the PDA@MNZ NPs exhibited synergistic therapy for periodontitisin . PDA@MNZ NPs were confirmed with exceptional antimicrobial and antioxidant functions, offering a promising avenue for synergistic therapy in periodontitis.