Genomic characterization of the species complex, a prominent member of the human skin microbiome.

mSystems

Microbial Genomics Section, Translational and Functional Genomics Branch, NHGRI, NIH, Bethesda, Maryland, USA.

Published: December 2023

Amplicon sequencing data combined with isolate whole genome sequencing have expanded our understanding of on the skin. Healthy human skin is colonized by a diverse collection of species, but predominates on many skin sites. Our work supports the emerging idea that is a species complex encompassing several distinct species. We produced a collection of genomes that help define this complex, including a potentially new species we term based on a preference for sites on the feet, whole-genome average nucleotide identity, pangenomic analysis, and growth in skin-like media. This isolate collection and high-quality genome resource set the stage for developing engineered strains for both basic and translational clinical studies.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10790575PMC
http://dx.doi.org/10.1128/msystems.00632-23DOI Listing

Publication Analysis

Top Keywords

species complex
8
human skin
8
species
5
genomic characterization
4
characterization species
4
complex prominent
4
prominent member
4
member human
4
skin
4
skin microbiome
4

Similar Publications

Morphological and phylogenetic analyses reveal two new species of the (Hypocreales, Nectriaceae) species complex in China.

MycoKeys

January 2025

The Key Laboratory for Silviculture and Conservation of the Ministry of Education, Beijing Forestry University, Beijing 100083, China Beijing Forestry University Beijing China.

The species complex (FFSC) encompasses a diverse array of more than 80 phylogenetic species with both phytopathological and clinical importance. A stable taxonomy is crucial for species in the FFSC due to their economical relevance. Fungal strains used in this study were obtained from and , collected from Beijing and Shaanxi Province.

View Article and Find Full Text PDF

Incorporating ecological connectivity into spatial conservation planning is increasingly recognized as a key strategy to facilitate species movements, especially under changing environmental conditions. However, obtaining connectivity data is challenging, especially in the marine realm. Sea currents are essential for exploring marine structural connectivity, but transforming sea current data into spatial connectivity matrices involves complex and resource-intensive processing steps to ensure accuracy and usability.

View Article and Find Full Text PDF

Diagnostic delays prevent most Chagas disease patients from receiving timely therapy during the acute phase when treatment is effective. qPCR-based diagnostic methods provide high sensitivity during this phase but require specialized equipment and complex protocols. More simple and cost-effective tools are urgently needed to optimize early Chagas disease diagnosis in low-income endemic regions.

View Article and Find Full Text PDF

Conversion therapy strategy: A novel GPC3-targeted multimodal organic phototheranostics platform for mid-late-stage hepatocellular carcinoma.

Mater Today Bio

February 2025

Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.

Hepatocellular carcinoma (HCC) is typically diagnosed at intermediate to advanced stage, making surgical treatment unfeasible. Conversion therapy aims to reduce tumor stage, improve hepatic resection feasibility, and lower recurrence rates. Since traditional therapies are often accompanied by uncertainty of efficacy, there is an urgent need to explore new treatment strategies.

View Article and Find Full Text PDF

The genus , a group of ciliated protists, has attracted attention as a model organism due to its widespread distribution and ease of cultivation. This study examines the evolutionary patterns of the SSU rRNA secondary structure within this genus, aiming to elucidate its role in supporting evolutionary relationships and uncovering cryptic species. By predicting the secondary structure of SSU rRNA and applying the CBC (Compensatory Base Change) concept analysis, we examined 69 species of the genus , with 57 SSU rRNA gene sequences retrieved from GenBank and 12 newly sequenced specimens from South Korea.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!