Malignant triton tumor (MTT) is a highly aggressive malignant neoplasm, classified as a variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. There are few reports that MTT occurred in urogenital system. In the present study, we report the first MTT occurring in the uterus. A 57-year-old woman came to the emergency department due to persistent vaginal bleeding for 2 months. The gynecological palpation found that a club-shaped excrescence existed in the vagina about 7 cm × 3 cm × 3 cm. The mass located in the lower segment of the uterus and the cervix was confirmed by gynecological vaginal ultrasound and magnetic resonance imaging, which was preliminarily diagnosed as cervical carcinoma. After neoplasm punch biopsy, the pathological diagnosis was malignant triton tumor. The patient finally lost follow-up. This is the first report about MTT in the uterus and suggests that pathological biopsy combined with imaging examination is necessary for the diagnosis of rarely MTT.
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http://dx.doi.org/10.1002/jcu.23630 | DOI Listing |
Liposarcomas are the most common soft tissue sarcoma primarily originating in deep soft tissues and the retroperitoneum. Sarcoma classification includes atypical lipomatous tumor/well-differentiated liposarcoma (WDL) and dedifferentiated liposarcoma (DDL), myxoid liposarcoma, and pleomorphic liposarcoma. DDL is most prevalent in the retroperitoneum and often has two distinct components, a well-differentiated lipomatous component and a dedifferentiated nonlipomatous component that could be morphologically similar to malignant fibrous histiocytoma (MFH) or fibrosarcoma.
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Department of Surgery, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ 07756, United States.
Low-grade appendiceal mucinous neoplasm (LAMN) is a rare entity identified in ~1% of patients undergoing appendectomy. The presentation often varies, making diagnosis challenging. Timely identification and treatment are critical to prevent rupture, which may lead to pseudomyxoma peritonei.
View Article and Find Full Text PDFCell
December 2024
New York Genome Center, New York, NY 10013, USA; Department of Biology, New York University, New York, NY 10013, USA. Electronic address:
Mammalian genomes host a diverse array of RNA that includes protein-coding and noncoding transcripts. However, the functional roles of most long noncoding RNAs (lncRNAs) remain elusive. Using RNA-targeting CRISPR-Cas13 screens, we probed how the loss of ∼6,200 lncRNAs impacts cell fitness across five human cell lines and identified 778 lncRNAs with context-specific or broad essentiality.
View Article and Find Full Text PDFIn Vivo
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Department of Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
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