AI Article Synopsis
- Stereotactic body radiation therapy (SBRT) for ultra-central lung tumors has high toxicity rates.
- The proximal bronchial tree (PBT) was divided into seven sections to study differences in radiosensitivity.
- A risk-adapted SBRT regimen with a specific dose has shown excellent tumor control and lower severe toxicity rates, with a modeling study suggesting a dose threshold for low bronchial toxicity.
Article Abstract
•Stereotactic body radiation therapy (SBRT) for ultra-central lung tumors is associated with high toxicity rates.•To evaluate differences in radiosensitivity within the proximal bronchial tree (PBT), the PBT was sub-segmented into seven anatomical sections.•A risk-adapted SBRT regimen of EQD2_10 = 54.4 Gy in 8 or 10 fractions results in excellent local control and low rates of severe toxicity.•Data from a recent -analysis, the NORDIC Hilus trial and dosimetric data from this study were combined to create a NTCP model.•A dose threshold of EQD2_3 = 100 Gy to the PBT or any of its subsegments is expected to result in low rates of severe bronchial toxicity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10731610 | PMC |
| http://dx.doi.org/10.1016/j.ctro.2023.100707 | DOI Listing |
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