AI Article Synopsis
- * The CONUT score was found to be an independent predictor of overall survival, with a hazard ratio of 1.11, and effectively stratified patients based on prognosis using a cutoff value of 3.
- * Additionally, the CONUT score influenced the initial dose intensity of treatment, indicating that nutritional status at diagnosis can affect treatment adjustments and overall outcomes for these patients.
Article Abstract
Predicting prognosis is crucial in older patients with diffuse large B-cell lymphoma (DLBCL). This study evaluated the prognostic impact of the controlling nutritional status (CONUT) score, a simple nutritional index, for older DLBCL patients (≥65 years of age) treated with R-CHOP-like regimens in a retrospective, cohort study including 203 patients. The CONUT score was an independent prognostic factor for overall survival (hazard ratio 1.11, 95% confidence interval (CI) 1.01-1.21, = 0.032) in a multivariable Cox proportional hazards model. On receiver-operating characteristic analysis, the optimal cutoff value was 3. The CONUT score (≥3 or <3) effectively stratified older DLBCL patients, regardless of the International Prognostic Index ( = 0.71 for interaction). Further, the CONUT score independently affected initial dose intensity (odds ratio 0.84, 95% CI 0.73-0.95, = 0.008), likely reflecting the patients' status at diagnosis and affecting dose adjustments. In conclusion, the CONUT score is associated with a poorer prognosis in older DLBCL patients.
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| http://dx.doi.org/10.1080/10428194.2023.2295787 | DOI Listing |
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