Herbert Coddington Major (Fig. 1) was a late nineteenth century pioneer in neuropathology and comparative neurology. No previous biographical article has been identified, suggesting he is now almost totally, yet unjustifiably, forgotten.
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Brain Struct Funct
September 2024
Department of Psychology, Division of Brain, Behavior and Cognition, Aristotelian University Faculty of Philosophy, Thessaloníki, Greece.
The study of cortical cytoarchitectonics and the histology of the human cerebral cortex was pursued by many investigators in the second half of the nineteenth century, such as Jacob Lockhart Clarke, Theodor Meynert, and Vladimir Betz. Another of these pioneers, whose name has largely been lost to posterity, is considered here: Herbert Coddington Major (1850-1921). Working at the West Riding Asylum in Wakefield, United Kingdom, Major's thesis of 1875 described and illustrated six-layered cortical structure in both non-human primates and man, as well as "giant nerve cells" which corresponded to those cells previously described, but not illustrated, by Betz.
View Article and Find Full Text PDFJ Neurol
April 2024
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK.
Herbert Coddington Major (Fig. 1) was a late nineteenth century pioneer in neuropathology and comparative neurology. No previous biographical article has been identified, suggesting he is now almost totally, yet unjustifiably, forgotten.
View Article and Find Full Text PDFAnn R Coll Surg Engl
January 1993
Breast Screening Unit, Royal South Hants Hospital, Southhampton.
With the natural history and optimal treatment of a high proportion of screen-detected breast cancers yet to be determined, treatment poses the management team with a number of therapeutic dilemmas. This study surveys the management policy and treatment of a consecutive series of 100 screen-detected cancers treated in a single breast unit. The problems encountered are discussed.
View Article and Find Full Text PDFCytopathology
February 1994
Southampton and Salisbury Breast Screening Unit, Royal South Hants Hospital, UK.
Oestrogen receptor (ER) status of 77 cases of screen-detected breast cancer has been determined using cytological preparations. In 48% ER status was positive, which was the same proportion as that formed in a control group of age-matched patients with symptomatic breast carcinoma. Since the screen-detected group contained more low grade tumours, the percentage of ER-positive cases would be expected to be higher.
View Article and Find Full Text PDFJ R Soc Med
November 1991
University Surgical Unit, Southampton General Hospital.
This study investigates the histopathological characteristics of a consecutive series of 100 screen detected breast cancers in relation to residual disease. Tumour type, size, grade, resection margins and extent of primary or associated in situ disease were all assessed by one pathologist. Thirty-seven women underwent further surgery (wider excision or mastectomy) and the resected specimen was examined for residual in situ or invasive cancer.
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