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Protein-surface interactions in nano-scale biosensors for IL-6 detection using functional monolayers.
Nanoscale
January 2025
Institute Nanoscience - CNR-NANO, Center S3, via G. Campi 213/A, 41125, Modena, Italy.
A multiscale approach is employed to investigate the interaction dynamics between interleukin-6, a key cancer biomarker, and alkyl-functionalized surfaces, with the ultimate goal of guiding biosensor design. The study integrates classical molecular dynamics, Brownian dynamics simulations, and binding experiments to explore the adsorption dynamics and energetics of IL-6 on surfaces modified with self-assembled monolayers (SAMs). The comparative analysis reveals a dramatic effect on the interaction strength of IL-6 with a SAMs comprising a mix of charged and hydrophobic ligands.
View Article and Find Full Text PDFBackground: Physical activity is essential for preventing cognitive decline, stroke and dementia in older adults. A new cardiovascular diagnosis offers a critical window for positive lifestyle changes. However, sustaining physical activity behavior change remains challenging and the underlying mechanisms are poorly understood.
View Article and Find Full Text PDFUnlabelled: As sequencing costs decrease, short-read and long-read technologies are indispensable tools for uncovering the genetic drivers behind bacterial pathogen resistance. This study explores the differences between the use of short-read (Illumina) and long-read (Oxford Nanopore Technologies, ONT) sequencing in detecting antimicrobial resistance (AMR) genes in ESKAPE pathogens ( and ). Utilizing a dataset of 1,385 whole genome sequences and applying commonly used bioinformatic methods in bacterial genomics, we assessed the differences in genomic completeness, pangenome structure, and AMR gene and point mutation identification.
View Article and Find Full Text PDFSoil fertility differences due to tillage methods modulate maize yield formation at different planting densities.
Sci Rep
January 2025
Inner Mongolia Agricultural University, No. 275, XinJian East Street, Hohhot, 010019, China.
To address the problems of planting density and low soil nutrient content in maize cultivation and production in western Inner Mongolia. This study aims to elucidate the regulatory mechanism by which soil fertility augmentation affects maize yield formation under a variety of planting densities. In this study, nine soil fertility conditions were established by deep tillage, no-tillage and in situ straw return.
View Article and Find Full Text PDFEvaluating Variability in Decision-Making Among Spine Surgeons Treating Adult Spine Deformity.
Spine J
January 2025
The Ottawa Hospital - Civic Campus, 1053 Carling Ave, Ottawa, Ontario, Canada, K1Y4E9. Electronic address:
Background Context: Significant variability in the management of Adult Spinal Deformity (ASD) has been observed among spine surgeons worldwide. The variability among Canadian spine surgeons, a country with universal public healthcare, remains unknown.
Purpose: The study aims to evaluate areas of variability in the peri-operative optimization and surgical management of ASD among Canadian spine surgeons.
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