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Differential signaling by type-I and type-III interferons in mucosa. | LitMetric

Differential signaling by type-I and type-III interferons in mucosa.

Curr Opin Immunol

Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:

Published: February 2024

AI Article Synopsis

Article Abstract

Mucosal surfaces are barrier sites that protect the body from the outside environment. They have developed mechanisms to handle microbiota-associated triggers while remaining responsive to pathogens. Cells at mucosal surfaces rely on both the type-I and -III interferons (IFNs) as key cytokines to protect the epithelium itself and to prevent systemic spread of viral infections. Type-I and -III IFNs have been shown to use distinct receptors but similar JAK/STAT signaling cascades to elicit the induction of IFN-stimulated genes. These overlapping cascades led to the original hypothesis that both IFNs provided redundant functions at mucosal surfaces. However, accumulating evidence points toward a different model where each IFN provides a unique protective and homeostatic function as well as distinct antiviral protection to epithelial cells. This review will highlight recent work shedding light on the differences in how both type -I and -III IFNs induce receptor-mediated signaling to protect mucosal surfaces.

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Source
http://dx.doi.org/10.1016/j.coi.2023.102400DOI Listing

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