The increasing trends in antimicrobial resistance (AMR) continue to pose a significant threat to human health, with grave consequences in low- and middle-income countries. In collaboration with local governments and microbiology laboratories in South Asian and Southeast Asian countries, the Capturing Data on Antimicrobial Resistance Patterns and Trends in Use in Regions of Asia (CAPTURA) project worked to identify gaps and expand the volume of existing AMR data to inform decision-makers on how to best strengthen their national AMR surveillance capacity. This article describes overall project management processes and the strategies implemented to address the disruptive impact of the coronavirus disease 2019 (COVID-19) pandemic on the project activities across diverse contexts in different countries. Also, it assesses in-country team's feedback on the conduct of activities and their overall impact on project completion. The strategies employed were tailored to the specific context of each country and included increased communication and collaboration among consortium partners and in-country teams, as well as hiring of additional in-country team members. This paper highlights the importance of local representation and capacities as well as real-time (virtual) engagement with stakeholders, ensuring close monitoring of the local situation and ability to tailor context-specific mitigation strategies to continue project implementation during disruptive external circumstances.
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http://dx.doi.org/10.1093/cid/ciad549 | DOI Listing |
Schizophr Bull
December 2024
Department of Psychiatry, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Background And Hypothesis: Respective abnormal structural connectivity (SC) and functional connectivity (FC) have been reported in individuals with schizophrenia. However, transmodal associations between SC and FC following antipsychotic treatment, especially in female schizophrenia, remain unclear. We hypothesized that increased SC-FC coupling may be found in female schizophrenia, and could be normalized after antipsychotic treatment.
View Article and Find Full Text PDFPLoS One
December 2024
School of Economics and Management, Qingdao Agricultural University, Qingdao, Shandong Province, China.
In the context of the transformation of urban-rural dual economic structure, one of the important ways to realize urban-rural integrated development is to carry out county industrial structure upgrading. Based on the policy of returning home to start business as a quasi-natural experiment, this paper empirically analyzes the relationship between returning home to start business and upgrading of county industrial structure. Selecting 1997 counties across the country from 2000 to 2021 as the research sample, a multi-temporal double-difference model is used to test the impact of the place-based policy on county industrial structure and the mechanism of the impact, and the result confirms that the implementation of the pilot policy of returning home entrepreneurship plays a positive and obvious role in promoting the level of industrial development of county-level areas.
View Article and Find Full Text PDFPLOS Digit Health
December 2024
Department of Family Medicine, McMaster University, Ontario, Canada.
The Community Paramedicine at Clinic (CP@clinic) program is a community program that utilizes community paramedics to support older adults in assessing their risk factors, managing their chronic conditions, and linking them to community resources. The aim of this project is to design a low-cost, portable, secure, user-friendly database for CP@clinic sessions and pilot test the database with paramedics and older adult volunteers. The CP@clinic program database using the Microsoft Access software was first developed through consultation with the CP@clinic research team.
View Article and Find Full Text PDFDiscov Oncol
December 2024
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang, China.
Antibody-drug conjugates (ADCs) represent a novel class of targeted anti-tumor medications that utilize the covalent linkage between monoclonal antibodies and cytotoxic agents. This unique mechanism combines the cytotoxic potency of drugs with the targeting specificity conferred by antigen recognition. However, it is essential to recognize that many ADCs still face challenges related to off-target toxicity akin to cytotoxic payloads, as well as targeted toxicity and other potential life-threatening adverse effects, such as treatment-induced interstitial lung injury.
View Article and Find Full Text PDFDiscov Oncol
December 2024
Department of Hospital Infection Management, Zhongshan Hospital Qingpu Branch, Fudan University, Shanghai, 201700, China.
The aim of our research was to explore the character of autophagy related 12 (ATG12) in the development of hepatocellular carcinoma (HCC). A total of 145 HCC tissues as well as paired adjacent normal tissues were collected, then immunohistochemistry was conducted to access the expression of ATG12. HCC cells were transfected with pcDNA ATG12 or si-ATG12 to overexpress ATG12 or downregulate ATG12.
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