Unstable periodontal disease and its association with sleep-disordered breathing.

Periodontal therapy results in successful disease management for some patients, but patients whose periodontal disease cannot be managed with standard-of-care protocols are treated repeatedly without success. For this set of patients, a systemic rather than an oral origin is possible. This clinical study investigated the connection between unresolved periodontal disease and sleep-disordered breathing (SDB) in 71 patients (44 women and 27 men), aged 19 to 75 years (mean, 45 years), who were enrolled in periodontal maintenance therapy for Stage I or II periodontitis. The results of an at-home sleep testing device served as the basis for evaluating 4 SDB screening tools: Papillary Bleeding Index (PBI), Epworth Sleepiness Scale (ESS) questionnaire, STOP-Bang questionnaire, and salivary cortisol testing. At-home sleep testing indicated that 33 participants had an apnea-hypopnea index ≥ 5, signifying probable obstructive sleep apnea. A finding of unstable periodontal disease (PBI ≥ 2) was able to identify 21 of these 33 participants, while the ESS and STOP-Bang questionnaires identified only 2 and 6 participants, respectively. The difference between the PBI and both the ESS and STOP-Bang questionnaires was statistically significant (P < 0.05; 2-sample proportion test). There was no relationship between participants' cortisol levels and the PBI findings. This clinical study found a link between unresolved periodontal disease and SDB. The results of this study suggested that the PBI is a reliable, objective means for general dentists to identify SDB in patients with unresolved periodontal disease. Once identified, these patients can be referred for treatment to address their SDB, which may positively impact management of their periodontal disease.