AI Article Synopsis
- Idiopathic pulmonary fibrosis (IPF) is a serious lung disease characterized by progressive fibrosis, and new imaging techniques using F-labeled FAP ligands may improve diagnostic capabilities.
- Researchers conducted a study involving eight patients with IPF, using [F]FAPI-74-PET/CT scans alongside HRCT to evaluate lung fibrosis.
- Initial findings suggest that [F]FAPI-74 can effectively assess fibrotic changes in the lungs, indicating its potential as a non-invasive diagnostic tool for IPF.
Article Abstract
Unlabelled: Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis. Ga-labeled FAP ligands exhibited highly promising results due to the crucial role of activated fibroblasts in fibrosis imaging of the lung. However, F-labeled FAP ligands might provide qualitatively much higher imaging results with accompanying economic benefits due to large-scale production. Thus, we sought to investigate the potential of [F]FAPI-74 prospectively in a small patient cohort.
Methods: Eight patients underwent both [F]FAPI-74-PET/CT and HRCT scans and were then compared with a control group without any fibrosing pulmonary disease. The tracer uptake of fibrotic lung areas was analyzed in synopsis with radiological and clinical parameters.
Results: We observed a positive correlation between the fibrotic active volume, the Hounsfield scale, as well as the vital and diffusing capacity of the lung.
Conclusion: The initial results confirm our assumption that [F]FAPI-74 offers a viable non-invasive assessment method for pulmonary fibrotic changes in patients with IPF.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043111 | PMC |
| http://dx.doi.org/10.1007/s00259-023-06564-y | DOI Listing |
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