AI Article Synopsis
- Early detection of postoperative complications in colorectal cancer surgery can improve patient outcomes, and this study aims to identify metabolic signatures that indicate risk for severe complications.
- Researchers analyzed plasma samples from 146 patients before and after surgery, using mass spectrometry to identify 188 metabolites and their ratios, finding significant associations between metabolic changes and the severity of complications.
- Key findings showed that specific metabolite ratios, particularly kynurenine/tryptophan and lysophosphatidylcholines, could predict a patient's risk for major complications, potentially guiding early intervention strategies to enhance surgical outcomes.
Article Abstract
Background: Early detection of postoperative complications after colorectal cancer (CRC) surgery is associated with improved outcomes. The aim was to investigate early metabolomics signatures capable to detect patients at risk for severe postoperative complications after CRC surgery.
Materials And Methods: Prospective cohort study of patients undergoing CRC surgery from 2015 to 2018. Plasma samples were collected before and after surgery, and analyzed by mass spectrometry obtaining 188 metabolites and 21 ratios. Postoperative complications were registered with Clavien-Dindo Classification and Comprehensive Complication Index.
Results: One hundred forty-six patients were included. Surgery substantially modified metabolome and metabolic changes after surgery were quantitatively associated with the severity of postoperative complications. The strongest positive relationship with both Clavien-Dindo and Comprehensive Complication Index (β=4.09 and 63.05, P <0.001) corresponded to kynurenine/tryptophan, against an inverse relationship with lysophosphatidylcholines (LPCs) and phosphatidylcholines (PCs). Patients with LPC18:2/PCa36:2 below the cut-off 0.084 µM/µM resulted in a sevenfold higher risk of major complications (OR=7.38, 95% CI: 2.82-21.25, P <0.001), while kynurenine/tryptophan above 0.067 µM/µM a ninefold (OR=9.35, 95% CI: 3.03-32.66, P <0.001). Hexadecanoylcarnitine below 0.093 µM displayed a 12-fold higher risk of anastomotic leakage-related complications (OR=11.99, 95% CI: 2.62-80.79, P =0.004).
Conclusion: Surgery-induced phospholipids and amino acid dysregulation is associated with the severity of postoperative complications after CRC surgery, including anastomotic leakage-related outcomes. The authors provide quantitative insight on metabolic markers, measuring vulnerability to postoperative morbidity that might help guide early decision-making and improve surgical outcomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10942180 | PMC |
| http://dx.doi.org/10.1097/JS9.0000000000000965 | DOI Listing |
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