Background: This study aims to investigate the effects of T4 and TD3 probiotics on skeletal muscle inflammation and oxidative stress in C57BL/6J mice fed a high-fat diet (HFD).
Methods: Probiotics T4, and TD3 were administered to male C57BL/6J mice fed with HFD. The gene expression of macrophage infiltration markers, inflammatory cytokines, and oxidative stress indicators in the muscle tissue was investigated.
Results: Treatment with T4 and TD3 reduced macrophage infiltration, accompanied by a decrease in the expression of monocyte chemoattractant protein-1 (MCP-1) and an increase in the expression of interleukin (IL)-10. On the other hand, TD3 decreased malondialdehyde (MDA) while T4 decreased carbonyl and increased catalase activity.
Conclusions: Treatment with probiotics T4 and TD3 partially ameliorated obesity-induced skeletal muscle inflammation in HFD-fed mice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10728858 | PMC |
| http://dx.doi.org/10.5812/ijpr-135249 | DOI Listing |
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