The genes encoding the mitogen-activated protein kinases DRL-1 and FLR-4 are required for growth and lipid homeostasis in . Interestingly, the mutant, which was previously isolated in a forward genetic screen for mutations that confer fluoride resistance, phenocopies the and loss-of-function mutants; however, the genetic identity of is unknown. Through whole genome sequencing, we found that the mutation is an insertion in the locus and disrupts gene function, resulting in dramatic growth defects and impaired vitellogenin production.
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| http://dx.doi.org/10.17912/micropub.biology.001047 | DOI Listing |
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