AI Article Synopsis
- - The study investigated the link between neonatal levels of complement proteins C3 and C4 and the risk of six mental disorders in a large sample of 68,768 newborns.
- - Genome-wide association studies (GWAS) identified multiple genetic loci related to C3 and C4 concentrations, but overall, no major associations with mental disorders were found in the total sample.
- - A notable finding was that higher C3 levels were linked to a lower risk of schizophrenia specifically in females, and C4 was associated with altered risk for five autoimmune disorders through Mendelian randomization.
Article Abstract
Complement components have been linked to schizophrenia and autoimmune disorders. We examined the association between neonatal circulating C3 and C4 protein concentrations in 68,768 neonates and the risk of six mental disorders. We completed genome-wide association studies (GWASs) for C3 and C4 and applied the summary statistics in Mendelian randomization and phenome-wide association studies related to mental and autoimmune disorders. The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between neonatal C3 and C4 concentrations and mental disorders in the total sample (both sexes combined); however, post-hoc analyses found that a higher C3 concentration was associated with a reduced risk of schizophrenia in females. Mendelian randomization based on C4 summary statistics found an altered risk of five types of autoimmune disorders. Our study adds to our understanding of the associations between C3 and C4 concentrations and subsequent mental and autoimmune disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726496 | PMC |
| http://dx.doi.org/10.1016/j.xgen.2023.100457 | DOI Listing |
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