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The ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): Results from the OSIPI-Dynamic Contrast-Enhanced challenge. | LitMetric

AI Article Synopsis

  • Purpose of the study was to standardize quantitative imaging methods for tumors, specifically using DCE-MRI, through the OSIPI-DCE challenge to benchmark these methods.
  • Methods involved creating a framework for evaluating DCE-MRI analysis submissions from the perfusion MRI community, focusing on glioblastoma quantification and requiring detailed reporting of procedures and software.
  • Results showed significant variability in software performance, with scores indicating differences in accuracy, repeatability, and reproducibility, while highlighting the importance of standardized procedures for improving analysis consistency.

Article Abstract

Purpose: has often been proposed as a quantitative imaging biomarker for diagnosis, prognosis, and treatment response assessment for various tumors. None of the many software tools for quantification are standardized. The ISMRM Open Science Initiative for Perfusion Imaging-Dynamic Contrast-Enhanced (OSIPI-DCE) challenge was designed to benchmark methods to better help the efforts to standardize measurement.

Methods: A framework was created to evaluate values produced by DCE-MRI analysis pipelines to enable benchmarking. The perfusion MRI community was invited to apply their pipelines for quantification in glioblastoma from clinical and synthetic patients. Submissions were required to include the entrants' values, the applied software, and a standard operating procedure. These were evaluated using the proposed score defined with accuracy, repeatability, and reproducibility components.

Results: Across the 10 received submissions, the score ranged from 28% to 78% with a 59% median. The accuracy, repeatability, and reproducibility scores ranged from 0.54 to 0.92, 0.64 to 0.86, and 0.65 to 1.00, respectively (0-1 = lowest-highest). Manual arterial input function selection markedly affected the reproducibility and showed greater variability in analysis than automated methods. Furthermore, provision of a detailed standard operating procedure was critical for higher reproducibility.

Conclusions: This study reports results from the OSIPI-DCE challenge and highlights the high inter-software variability within estimation, providing a framework for ongoing benchmarking against the scores presented. Through this challenge, the participating teams were ranked based on the performance of their software tools in the particular setting of this challenge. In a real-world clinical setting, many of these tools may perform differently with different benchmarking methodology.

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Source
http://dx.doi.org/10.1002/mrm.29909DOI Listing

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