This study aims to prepare vitexin albumin nanoparticles(VT-BSA-NPs) to alleviate the low bioavailability of vitexin(VT) in vivo due to its poor water solubility. VT micro powders were prepared by the antisolvent crystallization method, and the morphology, size, and physicochemical properties of VT micro powders were studied. The results showed that the VT micro powder had a particle size of(187.13±7.15) nm, an approximate spherical morphology, and a uniform size distribution. Compared with VT, the chemical structure of VT micro powders has not changed. VT-BSA-NPs were prepared from VT micro powders by desolvation-crosslinking curing method. The preparation process was screened by single factor test and orthogonal test, and the quality evaluation of the optimal prescription particle size, PDI, Zeta potential, EE, and morphology was performed. The results showed that the average particle size of VT-BSA-NPs was(124.33±0.47) nm; the PDI was 0.184±0.012; the Zeta potential was(-48.83±2.20) mV, and the encapsulation rate was 83.43%±0.39%, all of which met the formulation-related requirements. The morphological results showed that the VT-BSA-NPs were approximately spherical in appearance, regular in shape, and without adhesion on the surface. In vitro release results showed a significantly reduced release rate of VT-BSA-NPs compared with VT, indicating a good sustained release effect. LC-MS/MS was used to establish an analytical method for in vivo analysis of VT and study the plasma pharmacokinetics of VT-BSA-NPs in rats. The results showed that the specificity of the analytical method was good, and the extraction recovery was more than 90%. Compared with VT and VT micro powders, VT-BSA-NPs could significantly increase AUC, MRT, and t_(1/2), which was beneficial to improve the bioavailability of VT.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20230627.301 | DOI Listing |
Zhongguo Zhong Yao Za Zhi
October 2024
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China.
This study aims to reveal the effects and mechanisms of different fractions of Polygonati Rhizoma on the reproductive dysfunction in male mice with kidney essence deficiency due to excess of sexual intercourse. Fifty male ICR mice with good sexual function were selected and randomized into normal(NC), model(MC), n-butanol fraction of Polygonati Rhizoma(0.4 g·kg~(-1), HJCT), remaining fraction of Polygonati Rhizoma(0.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
December 2024
Department of Civil Engineering, National Institute of Technology Rourkela, Rourkela, India.
The disposal of waste glass is an environmental concern to municipal solid waste management authorities. An effective approach for reducing the environmental burdened and disposal problems with waste glass is its reuse in the construction industry. Hence, the feasible utilization of glass powder (GP) was assessed by studying the strength properties of the slag-GP binary geopolymers cured at different curing regimens.
View Article and Find Full Text PDFDrug Des Devel Ther
December 2024
Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People's Republic of China.
Objective: Depression and osteoporosis are usually concurrent health problems. This study aimed to explore the development of osteoporosis in depressive mice model and investigate the beneficial effects of the classical herbal formula Chaihu-Shugan-San (CHSG) on the brain and bone.
Methods: CHSG powder was prepared by spray-drying following extraction with water.
Materials (Basel)
December 2024
State Key Laboratory of South China Sea Marine Resources Utilization, School of Materials Science and Engineering, Hainan University, Haikou 570100, China.
The enhancement of the utilization rate of solid waste, along with balancing the comprehensive performance of materials, presents a significant challenge in the development of new functional building materials. This study examined the effects of high concentrations of iron tailing powder on the crystallization characteristics, pore structure, compressive strength, and water absorption of modified magnesium oxysulfate (MOS) foam cement with different dry densities. Furthermore, employing chemical foaming technology, the study characterized and analyzed the microstructure of modified MOS foam cement hydration products through scanning electron microscopy (SEM) and X-ray diffraction analysis (XRD).
View Article and Find Full Text PDFMaterials (Basel)
November 2024
Faculty of Mechanical Engineering and Ship Technology, Department of Manufacturing and Production Engineering, Institute of Machine and Materials Technology, Gdańsk University of Technology, G. Narutowicza Str. 11/12, 80-233 Gdańsk, Poland.
Nowadays, high requirements imposed by mechanical components make it necessary to develop modern production methods. Additive technologies have been dynamically developing in recent years, showing many advantages associated with the fabrication of elements with complex geometries and structures. One of the areas where the potential of additive technologies is exploited is the rapid tooling sector, which is based on the rapid production of tools and components used in various manufacturing methods.
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