A method for aromatic halogenation using a combination of elemental sulfur (S) and -halosuccinimide has been developed. A catalytic quantity of elemental sulfur (S) with -bromosuccinimide (NBS) and -chlorosuccinimide (NCS) effectively halogenated less-reactive aromatic compounds, such as ester-, cyano-, and nitro-substituted anisole derivatives. No reaction occurred in the absence of S, underscoring its crucial role in the catalytic activity. This catalytic system was also applicable to aromatic iodination with 1,3-diiodo-5,5-dimethylhydantoin.
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| http://dx.doi.org/10.1021/acs.joc.3c02259 | DOI Listing |
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