AI Article Synopsis
- The study investigates how juvenile adjuvant-induced arthritis (JAA) affects dental health in rats, focusing on carious tooth lesions.
- Experimental rats showed a significant increase in the number and depth of carious lesions compared to intact rats, with JAA leading to 100% prevalence of dental caries among them.
- The findings highlight the detrimental impact of autoimmune diseases like JAA on dental health, indicating a shift toward more severe carious cavities in affected rats.
Article Abstract
Objective: The aim: To study the intensity and depth of carious tooth lesions in rats with experimental juvenile adjuvant-induced arthritis.
Patients And Methods: Materials and methods: An experimental study on a model of juvenile adjuvant arthritis (JAA) in 10 one-month-old rats induced by method of A.M. Bendele was carried out. 10 rats of the same age were intact. Injection of adjutant in rats of experimental group led to the development of acute local reaction and then caused generalized joint reaction of autoimmune origin. The performed basic therapy of JAA promoted transition of acute autoimmune process to chronic. Rats were withdrawn from the experiment in 58 days and the dental-jaw blocks were made, in which the intensity and depth of carious lesions of the masticatory group of teeth were determined.
Results: Results: The course of JAA was accompanied by the development of dental caries in 100% of experimental animals. It was found that the intensity of carious teeth lesions in terms of the number of carious teeth and cavities is probably higher than in intact rats (respectively 4.3 ± 0.3 vs. 2.2 ± 0.6 and 4.5 ± 0.3 vs. 2.3 ± 0.7, p <0.001). In rats with JAA, mostly middle and deep carious cavities were revealed, at the same time in intact rats - superficial and middle carious cavities were observed.
Conclusion: Conclusions: It has been established that adjuvant arthritis is accompanied by 100% prevalence of dental caries, high intensity of carious process, presence of middle and deep carious cavities, that confirm the negative influence of autoimmune disease on the condition of the hard tooth tissues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.36740/WLek202311107 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oncologic and fertility outcomes in patients with juvenile granulosa cell tumor - a retrospective single centre analysis.
Gynecol Oncol
November 2024
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; UO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. Electronic address:
Background: Granulosa cell tumors (GCTs) are rare neoplasia that account for less than 5 % of all the ovarian tumors. Juvenile GCT histotype is generally observed in adolescent and young women, representing a very rare disease, so only a paucity of data are present in literature. The aim of this study is to analyse the oncologic and fertility outcome in our case series of juvenile GCTs.
View Article and Find Full Text PDFAn assessment of a GMP schistosomiasis vaccine (SchistoShield).
Front Trop Dis
July 2024
PAI Life Sciences, Seattle, WA, United States.
Introduction: Schistosomiasis is a neglected tropical disease that puts over 200 million people at risk, and prevention options are sparse with no approved vaccine. Our vaccine candidate, SchistoShield, is based on an approximately 87 kDa large subunit of calcium activated neutral protease - termed Sm-p80 - combined with a potent TLR4 agonist-based adjuvant. SchistoShield has been shown to prevent disease throughout the parasitic life cycle - including egg, juvenile, and adult worm stages - in numerous animal models up to and including baboons.
View Article and Find Full Text PDFOuter membrane vesicles (OMVs) from Tenacibaculum maritimum as a potential vaccine against fish tenacibaculosis.
Fish Shellfish Immunol
November 2024
Department of Microbiology and Parasitology, Aquatic One Health Research Center (iARCUS) and Faculty of Biology-CIBUS, University of Santiago de Compostela, Santiago de Compostela, Spain. Electronic address:
Outer membrane vesicles (OMVs) have been gained increasing attention in vaccinology due to their ability to induce strong protective humoral and cell-mediated immunity. The Gram-negative bacterium Tenacibaculum maritimum, the causative agent of marine tenacibaculosis, poses a significant challenge to the global aquaculture industry due to its difficult prophylaxis. In previous studies, we demonstrated that OMV production is a key virulence mechanism in T.
View Article and Find Full Text PDF[Recurrent respiratory papillomatosis].
Rev Med Suisse
October 2024
Service d'ORL et de chirurgie cervicofaciale, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Recurrent respiratory papillomatosis is a chronic infection of the airway mucosa by the human papilloma virus, in the form of recurrent exophytic papilloma. Two clinical forms are distinguished: juvenile and adult onset. Depending on their size and location, papilloma can cause dysphonia, pharyngeal discomfort, until obstruction of the airway.
View Article and Find Full Text PDFThe assessment of bone health in children with juvenile idiopathic arthritis; comparison of different imaging-based methods.
Pediatr Rheumatol Online J
August 2024
Section of Paediatric Radiology, University Hospital of North Norway, Tromsø, Norway.
Background: Osteoporosis is increasingly being recognized in children, mostly secondary to systemic underlying conditions or medication. However, no imaging modality currently provides a full evaluation of bone health in children. We compared DXA, a radiographic bone health index (BHI (BoneXpert) and cone-beam CT for the assessment of low bone mass in children with juvenile idiopathic arthritis (JIA).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!