AI Article Synopsis
- The study aimed to investigate liver function in chronic hepatitis C patients who also have chronic pancreatitis, particularly focusing on the role of pancreatic enzyme activity.
- 72 patients were analyzed: 52 with both CHC and pancreatic exocrine insufficiency (EI), and 20 with CHC but without EI; various liver and pancreatic function tests were performed.
- The results showed that patients with both CHC and CP with EI had significantly worse liver conditions, including higher levels of liver damage and fibrosis, alongside lower albumin levels compared to those without pancreatic insufficiency.
Article Abstract
Objective: The aim: To study the features of the functional state of the liver in patients with chronic hepatitis C (CHC) in the presence of CP, depending on the enzymatic activity of the pancreas.
Patients And Methods: Materials and methods: 72 patients were under observation: 52 with CHC and CP with exocrine secretory insufficiency (EI) of the pancreas and 20 - with CHC and CP without EI. In all patients, the degree of liver fibrosis, levels of aminotransferases, total bilirubin, gamma-glutamyltransferase, albumin, stool coproscopy and pancreatic fecal elastase-1 (FE-1) were determined.
Results: Results: It was revealed that in patients with CHC combined with CP+EI of the pancreas, higher activity of the necroinflammatory process and deeper stages of liver fibrosis is more often noted than in patients with preserved exocrine function of the pancreas. A statistically significant association was established between the degree of liver fibrosis and the presence of EI of the pancreas (p=0.03), namely, in patients with CHC and CP with EI of the pancreas, the degree of fibrosis F2-4 was 2.8 times more frequent. Also, higher levels of aminotransferases and lower levels of albumin were noted in this group of patients than in patients with CHC and CP with preserved exocrine function of the pancreatic gland.
Conclusion: Conclusions: In patients with CHC combined with CP+EI of the pancreas, higher levels of fibrosis and necroinflammatory activity of the liver are more often detected, as well as a tendency to lower albumin levels, than in patients with CHC and CP without EI.
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| http://dx.doi.org/10.36740/WLek202311103 | DOI Listing |
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