Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Diabetes and Metabolic Disease Clinical Research Center of Hubei Province, China; Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, China; Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases, China. Electronic address: