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Use of bee venom in preventive medicine: An experimental hepatic encephalopathy study in rats. | LitMetric

AI Article Synopsis

  • The study investigates the protective effects of bee venom against hepatic encephalopathy, a serious neurodegenerative disease, highlighting its potential as a preventive treatment beyond its current medicinal uses.
  • Healthy rats were divided into three groups: healthy, control (with induced hepatic encephalopathy), and a bee venom group that received bee venom before TAA administration, showing better locomotor activity in the bee venom group compared to the control.
  • Results indicate that bee venom may reduce blood ammonia levels and inflammation, suggesting it has protective effects against hepatic encephalopathy, making it a promising avenue for preventive medicine.

Article Abstract

Objectives: Bee venom is used for medicinal purposes, including the treatment of neurological and liver diseases, but its use as a primary health care approach for preventive purposes requires further exploration. The aim of this study was to provide the first investigation into the possible protective effects of bee venom against hepatic encephalopathy, a serious neurodegenerative disease.

Materials And Methods: An experimental animal study was conducted in which healthy albino Sprague-Dawley rats were randomized into three groups: healthy, control and bee venom groups. All rats were tested for locomotor activity at the beginning and end of the study. No intervention was made in the healthy group, whereas hepatic encephalopathy was induced in the control and bee venom groups by the administration of thioacetamide (TAA) (200 mg/kg/day). The bee venom group also received bee venom (5 mg/kg/day) subcutaneously every day for 14 days prior to the TAA administration.

Results: The results for the final locomotor activity tests were statistically better in the bee venom group than in the control group, supporting a beneficial effect of prophylactic bee venom application. Blood ammonia levels and liver weights, determined as indicators of inflammation, were lower in the bee venom group than in the control group and were close to levels in the healthy group, but not statistically significant.

Conclusions: Bee venom administration has protective effects against the development of hepatic encephalopathy and offers a promising therapeutic opportunity in preventive medicine.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766040PMC
http://dx.doi.org/10.1002/vms3.1336DOI Listing

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