Background And Objective: The incubation period of COVID-19 helps to determine the optimal duration of the quarantine and inform predictive models of incidence curves. Several emerging studies have produced varying results; this systematic review aims to provide a more accurate estimate of the incubation period of COVID-19.
Methods: For this systematic review, a literature search was conducted using Pubmed, Scopus/EMBASE, and the Cochrane Library databases, covering all observational and experimental studies reporting the incubation period and published from 1 January 2020 to 21 March 2020.We estimated the mean and 95th percentile of the incubation period using meta-analysis, taking into account between-study heterogeneity, and the analysis with moderator variables.
Results: We included seven studies (n = 792) in the meta-analysis. The heterogeneity (I 83.0%, p < 0.001) was significantly decreased when we included the study quality and the statistical model used as moderator variables (I 15%). The mean incubation period ranged from 5.6 (95% CI: 5.2 to 6.0) to 6.7 days (95% CI: 6.0 to 7.4) according to the statistical model. The 95 percentile was 12.5 days when the mean age of patients was 60 years, increasing 1 day for every 10 years.
Conclusion: Based on the published data reporting the incubation period of COVID-19, the mean time between exposure and onset of clinical symptoms depended on the statistical model used, and the 95th percentile depended on the mean age of the patients. It is advisable to record sex and age when collecting data in order to analyze possible differential patterns.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.rce.2020.08.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomarkers.
Alzheimers Dement
December 2024
Clinical Neurochemistry Laboratory Sahlgrenska University Hospital, Mölndal, Sweden.
Background: This research introduces a novel method for quantifying aggregated tau in body fluids, specifically cerebrospinal fluid (CSF), aiming to enhance the diagnosis and monitoring of neurodegenerative diseases, with a focus on Alzheimer's disease (AD).
Method: By combining tau protein amplification with a highly sensitive single-molecule array (Simoa) immunoassay using an anti-tau antibody CT19.1 in a homogenous manner, the approach enables precise measurements of tau aggregates in CSF.
Background: Currently there is no way to determine if archived cerebrospinal fluid (CSF) specimens have been properly handled and can be considered suitable for research purposes. Transthyretin (TTR) is abundant in CSF and undergoes a redox reaction that shifts its native proteoform into an S-cysteinylated form. This reaction proceeds spontaneously ex vivo when CSF is thawed, but ceases at storage temperatures of -80°C.
View Article and Find Full Text PDFSuitability of Rosaceae fruit tree species for Panonychus citri (McGregor) (Acari: Tetranychidae).
Exp Appl Acarol
January 2025
College of Plant Protection, Shandong Agricultural University, Tai'an, 271018, China.
The citrus red mite (CRM), Panonychus citri (McGregor) (Acari: Tetranychidae), a worldwide pest chiefly infesting Citrus plants, has spread from Southern China to Northern China. Little information is known about the population performance of CRM on the plants except for citrus trees and pear trees. In order to evaluate the extent of damage might caused by CRM to the fruit trees cultivated in Northern China, the performance of CRM on four Rosaceae species, including three main fruit tree species (pear-Pyrus pyrifolia Nakai cv.
View Article and Find Full Text PDFAtelocollagen-based hydrogel loaded with's extract for treatment of type 2 diabetic wounds.
Biomed Mater
January 2025
Department of Medical Microbiology, Kocaeli Universitesi, Faculty of Medicine Molecular Research and Antibody Laboratory, Kocaeli, 41001, TURKEY.
Diabetes, a chronic metabolic disease, causes complications such as chronic wounds which are difficult to cure. New treatments have been investigated to accelerate the wound healing. In this study, a novel wound dressing from fibroblast-laden atelocollagen-based hydrogel with Cotinus coggygria's extract was developed for diabetic wound healing.
View Article and Find Full Text PDFProteases from an Amazonian Mushroom Species: A Mycotechnological Alternative for the Production of Milk Coagulant.
Appl Biochem Biotechnol
January 2025
Post-Graduate Program in Biotechnology, Federal University of Amazonas (UFAM), Manaus, Amazonas, 69067-005, Brazil.
Edible mushrooms have been used as sustainable sources of proteases of industrial interest. The aim of this research was to investigate the influence of different culture media on mycelial growth and the potential of an Amazonian mushroom species, Auricularia fuscosuccinea DPUA 1624, in the biosynthesis of bovine milk coagulant enzymes. The species was cultivated on Sabouraud agar, malt, glucose, and peptone agar, malt extract agar, and glucose and peptone agar, supplemented with yeast extract for mycelial development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!