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| http://dx.doi.org/10.1161/JAHA.123.032647 | DOI Listing |
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Lipoprotein(a) Atherosclerotic Cardiovascular Disease Risk Score Development and Prediction in Primary Prevention From Real-World Data.
Circ Genom Precis Med
January 2025
Mary and Steve Wen Cardiovascular Division, Department of Medicine, University of California, Los Angeles. (W.F., N.D.W.).
Background: Lp(a; Lipoprotein[a]) is a predictor of atherosclerotic cardiovascular disease (ASCVD); however, there are few algorithms incorporating Lp(a), especially from real-world settings. We developed an electronic health record (EHR)-based risk prediction algorithm including Lp(a).
Methods: Utilizing a large EHR database, we categorized Lp(a) cut points at 25, 50, and 75 mg/dL and constructed 10-year ASCVD risk prediction models incorporating Lp(a), with external validation in a pooled cohort of 4 US prospective studies.
Association of T3/T4 ratio with inflammatory indicators and all-cause mortality in stroke survivors.
Front Endocrinol (Lausanne)
January 2025
Department of Neurosurgery, Huzhou Central Hospital, Huzhou, China.
Background: Abnormal thyroid hormone levels may occur in critical illness, which may have an interactive relationship with inflammatory reaction. At present, the relationship between triiodothyronine (T3)/thyroxine (T4) ratio and inflammatory indicators and all-cause mortality of stroke survivors is still unclear.
Methods: We obtained the relevant data of the respondents from 2007 to 2012 through the National Health and Nutrition Examination Survey (NHANES) database for statistical analysis.
Association of GLP1R locus with mental ill-health endophenotypes and cardiometabolic traits: A trans-ancestry study in UK Biobank.
Diabetes Obes Metab
January 2025
School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Aims: Glucagon-like peptide 1 receptor agonists (GLP1RA), used to treat type 2 diabetes and obesity, have been associated with off-target behavioural effects. We systematically assessed genetic variation in the GLP1R locus for impact on mental ill-health (MIH) and cardiometabolic phenotypes across diverse populations within UK Biobank.
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Test-retest reliability and responsiveness of an adapted version of the ABILHAND questionnaire to assess performance in bimanual daily life activities in stroke patients in sub-Saharan Africa.
Int J Rehabil Res
January 2025
Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale (Cirris).
The ABILHAND is a widely used questionnaire assessing bimanual daily life activities in adults with stroke. A recently modified version tailored for the sub-Saharan African population (ABILHAND-Stroke Benin) has been created. This study aimed to investigate its test-retest reliability and responsiveness.
View Article and Find Full Text PDFFrom stroke to depression: The need for systematic screening for post-stroke depression.
S Afr J Psychiatr
December 2024
Department of Internal Medicine, Cameroon Baptist Convention Health Services, Bamenda, Cameroon.
Background: Post-stroke depression (PSD) negatively impacts the physical and mental well-being of stroke survivors. However, data on the prevalence and risk factors of PSD in African countries such as Cameroon are limited.
Aim: This study aims to determine the prevalence and factors associated with PSD among stroke survivors at a hospital in Cameroon and inform clinical practice.
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